Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses.
Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses.
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DOI：
10.1016/j.psychres.2015.05.017
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发表时间：
2015-08-30
影响因子：
11.3
通讯作者：
Mathews CA
中科院分区：
文献类型：
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作者：
Darrow SM;Illmann C;Gauvin C;Osiecki L;Egan CA;Greenberg E;Eckfield M;Hirschtritt ME;Pauls DL;Batterson JR;Berlin CM;Malaty IA;Woods DW;Scharf JM;Mathews CA
收集神经精神疾病遗传分析所需的表型数据既耗时又昂贵。基于网络的表型评估的发展将极大地提高遗传研究的效率和成本效益。然而，与标准、深入的临床访谈相比，评估这种方法的可靠性是至关重要的。目前的研究复制并扩展了关于基于网络的抽动秽语综合症（TS）和常见合并症诊断（强迫症（OCD）和注意力缺陷/多动症（ADHD））的实用性初步报告。完成 TS 基因研究的网络表型评估的一部分人被邀请参加半结构化诊断临床访谈。这些访谈的数据用于通过最佳估计程序确定参与者对 TS、OCD 和 ADHD 的诊断状态，然后将其作为比较使用基于网络的屏幕数据分配的诊断的黄金标准。结果显示 TS 的一致性很高。 OCD 和 ADHD 诊断的 Kappas 也很高，并且共同证明了这种自我报告数据在比较临床医生之前的诊断和维度评估方法时的实用性。
Collecting phenotypic data necessary for genetic analyses of neuropsychiatric disorders is time consuming and costly. Development of web-based phenotype assessments would greatly improve the efficiency and cost-effectiveness of genetic research. However, evaluating the reliability of this approach compared to standard, in-depth clinical interviews is essential. The current study replicates and extends a preliminary report on the utility of a web-based screen for Tourette Syndrome (TS) and common comorbid diagnoses (obsessive compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD)). A subset of individuals who completed a web-based phenotyping assessment for a TS genetic study was invited to participate in semi-structured diagnostic clinical interviews. The data from these interviews were used to determine participants’ diagnostic status for TS, OCD, and ADHD using best estimate procedures, which then served as the gold standard to compare diagnoses assigned using web-based screen data. The results show high rates of agreement for TS. Kappas for OCD and ADHD diagnoses were also high and together demonstrate the utility of this self-report data in comparison previous diagnoses from clinicians and dimensional assessment methods.