Comparisons of cone electroretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macular hole surgery
Comparisons of cone electroretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macular hole surgery
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DOI：
10.1007/s00417-014-2594-6
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发表时间：
2014-09-01
影响因子：
2.7
通讯作者：
Kurosaka, Daijiro
中科院分区：
文献类型：
--
作者：
Machida, Shigeki;Toba, Yoshiharu;Kurosaka, Daijiro
为比较黄斑裂孔（MH）手术中吲哚菁绿色（ICG）辅助、亮蓝G（BBG）辅助和曲安奈德（TA）辅助内界膜（ILM）剥除术患者视网膜神经节细胞（RGCs）的明视负反应（PhNR）功能。BBG辅助或TA辅助玻璃体切除术（每组n = 16）。在术前和术后1、3、6、9和12个月记录全视野锥形ERG。测量a波和b波的振幅和隐式时间以及振荡电位（OPs）和PhNR的振幅。测量标准自动视野检查的平均偏差（MD）和最佳矫正视力（BCVA）。采用SD-OCT评价视网膜周围神经纤维层（RNFL）厚度，所有黄斑裂孔均闭合，最佳矫正视力（BCVA）和黄斑中心距（MD）均明显改善，各组间差异无统计学意义。术前与术后RNFL厚度差异无统计学意义。术后各组a波、b波潜伏期均明显延长，I OPs磅均明显降低。这些ERG变化在各组之间没有显著差异。ICG组术后PhNR波幅明显低于BBG组和TA组，提示PhNR可检测ICG可能的毒性作用引起的RGCs亚临床损害。这一发现增加了在MH手术期间使用BBG和TA可能比ICG更安全的数据。
To compare the function of retinal ganglion cells (RGCs) using the photopic negative response (PhNR) in patients who had undergone indocyaine green (ICG)-assisted, brilliant blue G (BBG)-assisted, or triamcinolone acetonide (TA)-assisted internal limiting membrane (ILM) peeling during macular hole (MH) surgery.Forty-eight eyes of 48 patients with a macular hole were randomly divided into those undergoing ICG-assisted, BBG-assisted, or TA-assisted vitrectomy (n = 16 for each group). Full-field cone ERGs were recorded before and 1, 3, 6, 9, and 12 months postoperatively. The amplitudes and implicit times of the a-waves and b-waves and the amplitudes of the oscillatory potentials (OPs) and PhNRs were measured. The mean deviations (MDs) of standard automated perimetry and the best-corrected visual acuity (BCVA) were measured. The circumferential retinal nerve fiber layer (RNFL) thickness was evaluated by SD-OCT.All macular holes were closed with a significant improvement of the BCVA and MD without differences among the groups. There was no significant difference between the preoperative and postoperative RNFL thickness. The implicit times of the a-waves and b-waves were significantly prolonged, and the I OPs pound amplitude was significantly decreased postoperatively in all groups. These ERG changes were not significantly different among the groups. The postoperative PhNR amplitudes were significantly lower in the ICG group than in the BBG or TA group.The results indicate that the PhNR may detect subclinical impairments of RGCs caused by the possible toxic effect of ICG. This finding adds to the data that BBG and TA may be safer than ICG for use during MH surgery.