Finding an “Achilles’ heel” of cancer: The role of glucose and glutamine metabolism in the survival of transformed cells
Finding an “Achilles’ heel” of cancer: The role of glucose and glutamine metabolism in the survival of transformed cells
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DOI：
10.4161/cc.7.14.6256
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发表时间：
2008-07
期刊：
影响因子：
4.3
通讯作者：
M. Yuneva
中科院分区：
文献类型：
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作者：
M. Yuneva
多种证据表明，肿瘤发生的过程往往与两种主要营养物质葡萄糖和谷氨酰胺的代谢改变有关。这两种营养素参与细胞活力所需的多种代谢途径。葡萄糖和谷氨酰胺在体外和体内转化细胞存活中的作用已经在各种细胞系统中分别进行了评估，葡萄糖作为主要的细胞能量来源受到了最多的关注。与此同时，数据表明，葡萄糖和谷氨酰胺纳入特定的代谢途径和细胞对这些营养素的可用性的敏感性取决于细胞来源和转化事件的组合和性质。利用细胞代谢来开发选择性癌症治疗剂需要考虑这些因素，并评估不同转化细胞存活所需的葡萄糖和谷氨酰胺代谢。在这里，我们讨论了可能的分子机制致癌基因诱导的敏感性剥夺这些营养素。
Multiple lines of evidence indicate that the process of tumorigenesis is often associated with altered metabolism of two major nutrients, glucose and glutamine. These two nutrients are engaged in multiple metabolic pathways that can be required for cell viability. The roles of glucose and glutamine in the survival of transformed cells both in vitro and in vivo have been separately evaluated in various cell systems, and glucose as the major cellular energy source has received most of the attention. At the same time, data suggests that the inclusion of glucose and glutamine into specific metabolic pathways and cellular sensitivity to the availability of either of these nutrients depends on the cell origin and the combination and nature of transforming events. Exploiting cell metabolism to develop selective cancer therapeutics requires consideration of these factors and evaluation of the requirement of glucose and glutamine metabolism for survival of different transformed cells. Here we discuss possible molecular mechanisms underlying oncogene-induced sensitivity to deprivation of these nutrients.