Impact of a New Sarco-Osteopenia Definition on Health-related Quality of Life in a Population-Based Cohort in Northern Europe
Impact of a New Sarco-Osteopenia Definition on Health-related Quality of Life in a Population-Based Cohort in Northern Europe
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DOI：
10.1016/j.jocd.2011.08.007
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发表时间：
2012-01-01
影响因子：
2.5
通讯作者：
Lember, Margus
中科院分区：
文献类型：
--
作者：
Kull, Mart;Kallikorm, Riina;Lember, Margus
肌肉减少症已被证明是跌倒的标志;因此，将骨质减少症和肌肉减少症结合起来可以识别出更虚弱、骨折风险更高的人群。我们的目的是使用肌肉功能和定量参数在基于人群的健康年轻样本中定义肌骨减少症（SOP），并评估该定义对健康相关生活质量的影响。使用Lunar DPX-IQ双能X射线吸收测量仪（GE Healthcare，Pollards Wood，UK）分析了304例年龄在25 - 70岁之间的患者的人群样本，并使用简明健康量表-36（SF-36）问卷评估了他们的健康相关生活质量。SOP定义为骨矿物质密度（BMD）-1标准差（SD）和身高调整后的肩胛骨肌质量-2 SD和/或握力-2 SD小于人群样本中77名年轻个体（年龄：25 - 39岁）的平均值。我们提出的SOP定义确定了3 - 9%的40岁以上人群为肌骨减少症。这些个体在SF-36问卷的角色-身体（p = 0.01）、活力（p = 0.03）和角色-情感（p = 0.02）分量表中的得分也明显较低。骨质疏松患者和BMD正常者的生活质量无差异。新的定义确定了与健康有关的生活质量显著下降的人口。
Sarcopenia has been shown to be a marker of falling; therefore, combining osteopenia and sarcopenia could identify a frailer, higher-fracture-risk population. We aimed to define sarco-osteopenia (SOP) in a population-based healthy young sample using both muscle functional and quantitative parameters and assessing the impact of this definition on health-related quality of life. A population sample of 304 patients aged 25-70 yr was analyzed with a Lunar DPX-IQ dual-energy X-ray absorptiometry machine (GE Healthcare, Pollards Wood, UK), and their health-related quality of life was assessed with the Short-Form-36 (SF-36) questionnaire. SOP was defined as bone mineral density (BMD) - 1 standard deviation (SD) and height-adjusted appendicular muscle mass -2 SD and/or grip strength -2 SD less than the mean values of 77 young individuals in the population sample (age: 25-39 yr). Our proposed SOP definition identifies 3-9% of the population older than 40 yr as sarco-osteopenic. These individuals also show markedly lower scores in the role-physical (p = 0.01), vitality (p = 0.03), and role-emotional (p = 0.02) subscales of the SF-36 questionnaire. No difference in the quality of life was observed between osteopenic individuals and those with normal BMD. The new definition identifies a population with significant decrements in health-related quality of life.