DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
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DOI：
10.1126/science.271.5247.350
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发表时间：
1996-01-19
期刊：
影响因子：
56.9
通讯作者：
Kern, SE
中科院分区：
文献类型：
--
作者：
Hahn, SA;Schutte, M;Kern, SE
大约90%的人类胰腺癌在18q染色体上显示等位基因丢失。为了确定18q上的候选肿瘤抑制基因，我们对一组胰腺癌进行了同源缺失的聚合位点分析。84个肿瘤中有25个在18q21.1位点有纯合缺失，该位点不包括DCC（结肠直肠癌的候选抑制基因），包括DPC4， DPC4是一种与果蝇基因（Mad）序列相似的基因，涉及转化生长因子- β (tgf - β)样信号通路。在18q21.1位点没有纯合缺失的27例胰腺癌中，有6例发现了潜在的DPC4失活突变。这些结果表明DPC4是一个候选的肿瘤抑制基因，其失活可能在胰腺和其他人类癌症中发挥作用。
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homboygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4, a gene similar in sequence to a Drosophila melanogaster gene (Mad) implicated in a transforming growth factor-beta (TGF-beta)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.