Insights into the function of IgD
Insights into the function of IgD
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DOI：
10.1016/j.dci.2011.03.002
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发表时间：
2011-12-01
影响因子：
2.9
通讯作者：
Wilson, Melanie
中科院分区：
文献类型：
--
作者：
Edholm, Eva-Stina;Bengten, Eva;Wilson, Melanie
IGD以前被认为是最近加入免疫球蛋白类别的，长期以来一直被认为是一个谜一样的分子。例如，除了作为与免疫球蛋白M在幼稚B细胞上共表达的抗原受体外，IGD是否具有特定的功能，以及它是否在哺乳动物免疫中发挥重要作用，这是有争议的。然而，在过去的十年中，对脊椎动物基因组的广泛测序表明，IGD同源物存在于除鸟类以外的所有脊椎动物分类群中。此外，最近的功能研究表明，IGD可能在脊椎动物的免疫反应中发挥着独特的作用。这篇综述的目的是总结IGD基因的组织和结构数据，这些数据表明IGD具有古老的起源，并讨论在鲶鱼和人类中的发现，为深入了解这种难以捉摸的免疫球蛋白同种类型的可能功能提供了线索。(C)2011爱思唯尔有限公司。保留所有权利。
IgD, previously thought to be a recent addition to the immunoglobulin classes, has long been considered an enigmatic molecule. For example, it was debated if IgD had a specific function other than as an antigen receptor co-expressed with IgM on naive B cells and if it had an important role in mammalian immunity. However, during the past decade extensive sequencing of vertebrate genomes has shown that IgD homologs are present in all vertebrate taxa, except for birds. Moreover, recent functional studies indicate that IgD likely performs a unique role in vertebrate immune responses. The goal of this review is to summarize the IgD gene organization and structural data, which demonstrate that IgD has an ancient origin, and discuss the findings in catfish and humans that provide insight into the possible function of this elusive immunoglobulin isotype. (C) 2011 Elsevier Ltd. All rights reserved.