Prediction of Sarcomere Mutations in Subclinical Hypertrophic Cardiomyopathy
Prediction of Sarcomere Mutations in Subclinical Hypertrophic Cardiomyopathy
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DOI：
10.1161/circimaging.114.002411
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发表时间：
2014-11-01
影响因子：
7.5
通讯作者：
Moon, James C.
中科院分区：
文献类型：
--
作者：
Captur, Gabriella;Lopes, Luis R.;Moon, James C.
Background-Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH). We have proposed that myocardial crypts are part of this phenotype and independently associated with the presence of sarcomere gene mutations. We tested this hypothesis in genetic hypertrophic cardiomyopathy pre-LVH (genotype positive, LVH negative [G+LVH-]).Methods and Results-A multicenter case-control study investigated crypts and 22 other cardiovascular magnetic resonance parameters in subclinical hypertrophic cardiomyopathy to determine their strength of association with sarcomere gene mutation carriage. The G+LVH- sample (n=73) was 29 +/- 13 years old and 51% were men. Crypts were related to the presence of sarcomere mutations (for >= 1 crypt, beta=2.5; 95% confidence interval [CI], 0.5-4.4; P=0.014 and for >= 2 crypts, beta=3.0; 95% CI, 0.8-7.9; P=0.004). In combination with 3 other parameters: anterior mitral valve leaflet elongation (beta=2.1; 95% CI, 1.7-3.1; P
