Use of polymer-supported dialkylphosphinobiphenyl ligands for palladium-catalyzed amination and Suzuki reactions.
Use of polymer-supported dialkylphosphinobiphenyl ligands for palladium-catalyzed amination and Suzuki reactions.
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DOI：
10.1021/jo010025w
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发表时间：
2001-05
期刊：
影响因子：
--
通讯作者：
Cynthia A. Parrish and;S. Buchwald
中科院分区：
文献类型：
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作者：
Cynthia A. Parrish and;S. Buchwald
报道了聚合物支载的二烷基膦基联苯配体（3）的制备。基于配体3a的钯催化剂对于使用未活化的芳基碘化物、溴化物或氯化物的胺化和Suzuki反应是活性的。从反应混合物中过滤催化剂允许通过水性后处理简化产物分离。在胺化和Suzuki反应中，树脂结合的催化剂可以在没有额外的钯的情况下再循环。
The preparations of polymer-supported dialkylphosphinobiphenyl ligands (3) are reported. A palladium catalyst based on ligand 3a is active for amination and Suzuki reactions using unactivated aryl iodides, bromides, or chlorides. Filtration of the catalyst from the reaction mixture allows for simplified product isolation via an aqueous workup. The resin-bound catalyst can be recycled without additional palladium in both the amination and Suzuki reactions.