Brain-derived neurotrophic factor Val66Met and neuropsychological functioning after early childhood traumatic brain injury.
Brain-derived neurotrophic factor Val66Met and neuropsychological functioning after early childhood traumatic brain injury.
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DOI：
10.1017/s1355617722000194
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发表时间：
2023-03
期刊：
影响因子：
--
通讯作者：
Kurowski BG
中科院分区：
文献类型：
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作者：
Treble-Barna A;Wade SL;Pilipenko V;Martin LJ;Yeates KO;Taylor HG;Kurowski BG
本研究探讨了脑源性神经营养因子（BDNF）Val 66 Met多态性对创伤性脑损伤（TBI）儿童相对于骨科损伤（OI）的神经心理功能的差异作用。参与者来自一项前瞻性纵向研究，研究对象为3至7岁的TBI（n=69）或OI（n=72）儿童。儿童完成了一系列针对注意力，记忆力和执行功能的神经心理学测量，在四个时间点，从急性期到受伤后18个月。在受伤后大约7年，儿童还完成了一系列与年龄相当的测量。父母在所有时间点对孩子的执行障碍行为进行评级。纵向混合模型揭示了一个显着的等位基因状态x损伤组的相互作用与中等效果大小的语言流畅性。损伤后7年的横断面模型显示，等位基因状态x损伤组相互作用对流体推理和即时和延迟言语记忆的影响不显著，但中等。事后分层分析显示，TBI组中Met携带者相对于瓦尔/瓦尔纯合子的神经心理功能较差的模式一致，效应量较小;在OI组中观察到相反的趋势或无明显效应。结果表明，在早期TBI相对于OI的儿童中，BDNF Val 66 Met多态性对语言流畅性，可能还有流体推理和即时和延迟的语言记忆有不同的影响。Met等位基因与BDNF活性依赖性分泌减少相关，可能导致TBI儿童神经心理功能较差的风险。
The present study examined the differential effect of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on neuropsychological functioning in children with traumatic brain injury (TBI) relative to orthopedic injury (OI). Participants were drawn from a prospective, longitudinal study of children who sustained a TBI (n=69) or OI (n=72) between 3 and 7 years of age. Children completed a battery of neuropsychological measures targeting attention, memory, and executive functions at four timepoints spanning the immediate post-acute period to 18 months post-injury. Children also completed a comparable age-appropriate battery of measures approximately 7 years post-injury. Parents rated children’s dysexecutive behaviors at all timepoints. Longitudinal mixed models revealed a significant allele status x injury group interaction with a medium effect size for verbal fluency. Cross-sectional models at 7 years post-injury revealed non-significant but medium effect sizes for the allele status x injury group interaction for fluid reasoning and immediate and delayed verbal memory. Post hoc stratified analyses revealed a consistent pattern of poorer neuropsychological functioning in Met carriers relative to Val/Val homozygotes in the TBI group, with small effect sizes; the opposite trend or no appreciable effect was observed in the OI group. The results suggest a differential effect of the BDNF Val66Met polymorphism on verbal fluency, and possibly fluid reasoning and immediate and delayed verbal memory, in children with early TBI relative to OI. The Met allele—associated with reduced activity-dependent secretion of BDNF—may confer risk for poorer neuropsychological functioning in children with TBI.