The prognostic significance of N-myc downregulated gene 1 in lung adenocarcinoma
The prognostic significance of N-myc downregulated gene 1 in lung adenocarcinoma
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DOI：
10.1111/pin.12644
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发表时间：
2018-04-01
影响因子：
2.2
通讯作者：
Noguchi, Masayuki
中科院分区：
文献类型：
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作者：
Dai, Tomoko;Dai, Yuichi;Noguchi, Masayuki
N-myc下游调节基因1（NDRG 1）与非小细胞肺癌（NSCLC）的预后有关，并与c-Myc在NSCLC细胞系中的降解有关。然而，NDRG 1与肺腺癌预后或c-Myc表达的关系尚未得到很好的阐明。本研究采用组织芯片免疫组化技术，探讨NDRG 1和/或c-Myc在肺腺癌中表达的预后意义。我们检测了184例肺腺癌，发现NDRG 1在原位腺癌（AIS）和微创腺癌（MIA）中低表达，而在浸润性腺癌中高表达。除年龄外，其他临床病理特征均与NDRG 1表达显著相关。Kaplan-Meier曲线显示NDRG 1高表达与低表达相比预后差（log-rank，P
It has been reported that N-myc downstream regulated gene 1 (NDRG1) is related to the prognosis of non-small cell lung cancer (NSCLC), and associated with c-Myc degradation in NSCLC cell lines. However, the relationship of NDRG1 to prognosis or c-Myc expression in lung adenocarcinoma has not been well clarified. The present study was designed to investigate the prognostic significance of NDRG1 and/or c-Myc expression in lung adenocarcinoma using immunohistochemistry with a tissue microarray. We examined 184 lung adenocarcinomas and observed low expression of NDRG1 in adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), whereas high expression of NDRG1 was seen in invasive adenocarcinoma. Each of the clinicopathological features except age was significantly correlated with NDRG1 expression. Kaplan-Meier curves indicated that high expression of NDRG1 was significantly correlated with poor prognosis in comparison with low expression (log-rank, P