Lipid unsaturation and organelle dynamics
Lipid unsaturation and organelle dynamics
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DOI：
10.1016/j.ceb.2016.03.012
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发表时间：
2016-08-01
影响因子：
7.5
通讯作者：
Antonny, Bruno
中科院分区：
文献类型：
--
作者：
Barelli, Helene;Antonny, Bruno
磷脂（PL）酰基链中双键（=不饱和度）的数量影响细胞膜的物理性质。在这里，我们讨论了不同的分子过程，包括囊泡出芽，离子通道开放，脂蛋白的形成，这是大大促进PL多不饱和膜。PL的结构和动力学的实验和基于计算机的方法提出了这些效应的共同原因：PL的多不饱和酰基链根据各种约束沿膜法线沿着延伸或弯曲的能力，从而使基本上是2D流体的结构中的第三维运动成为可能。
The number of double bonds (=unsaturation) in the acyl chains of phospholipids (PL) influences the physical properties of cellular membranes. Here, we discuss disparate molecular processes, including vesicle budding, ion channel opening, and lipoprotein formation, which are greatly facilitated by PL polyunsaturation in membranes. Experimental and computer-based approaches for the structure and dynamics of PL suggest a common cause for these effects: the ability of the polyunsaturated acyl chain of PL to extend or bent along the membrane normal according to various constraints, thereby enabling a third dimension of motion in a structure that is essentially a 2D fluid.