Persistent colonization of nine cystic fibrosis patients with an achromobacter (Alcaligenes) xylosoxidans clone
Persistent colonization of nine cystic fibrosis patients with an achromobacter (Alcaligenes) xylosoxidans clone
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DOI：
10.1007/s10096-004-1105-9
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发表时间：
2004-04-01
影响因子：
4.5
通讯作者：
Maniatis, AN
中科院分区：
文献类型：
--
作者：
Kanellopoulou, M;Pournaras, S;Maniatis, AN
本研究旨在调查从希腊雅典一家成人囊性纤维化科囊性纤维化患者的痰样本中分离出的xylosoxidans无色杆菌（以前称为Alcaligenes）的发病率增加情况。在1年的研究期间，71例囊性纤维化患者中有9例持续检测到34株分离株。分离株对多种抗微生物药物表现出耐药性。通过脉冲场凝胶电泳，从每位患者反复回收的分离株显示出相同的宏观限制谱，表明相同的菌株持续存在于这些患者的肺部。其中5例患者的分离株具有遗传相关性，提示木糖氧化无色杆菌定植或感染的共同来源暴发。
The present study was conducted to investigate the increasing incidence of Achromobacter (previously Alcaligenes) xylosoxidans isolates being recovered from sputum samples of cystic fibrosis patients at a cystic fibrosis department for adults in Athens, Greece. During the 1-year study period, a total of 34 isolates were detected persistently in 9 of 71 cystic fibrosis patients. The isolates exhibited resistance to multiple antimicrobial agents. Isolates that were recovered repeatedly from each patient exhibited identical macrorestriction profiles with pulsed-field gel electrophoresis, indicating that the same strain persisted in the lungs of these patients. Isolates from five of the patients were genetically related, suggesting a common-source outbreak of Achromobacter xylosoxidans colonization or infection.