Exposure to subcutaneously implanted uranium dioxide impairs bone formation
Exposure to subcutaneously implanted uranium dioxide impairs bone formation
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DOI：
10.1080/00039890209601415
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发表时间：
2002-07-01
期刊：
影响因子：
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通讯作者：
Cabrini, RL
中科院分区：
文献类型：
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作者：
Sylvester, PLD;L贸pez, R;Cabrini, RL
铀颗粒进入皮下组织是一种风险，影响到从事铀提取、纯化和制造的工人以及被铀弹片炸伤的士兵。作者评价了不溶性铀的内部来源对骨的影响。将二氧化铀粉末（0.125克/千克体重）皮下植入大鼠体内。30天后，接触铀的动物体重低于对照组。实验动物的软骨内骨化和骨生长中的骨形成活性也较低，如组织形态学和形态学方法所证明的。这是第一个研究报告骨损伤所造成的连续，非致命性暴露于不溶性化合物的二氧化铀超过30天。
The introduction of uranium particles into subcutaneous tissue is a risk that affects workers engaged in the extraction, purification, and manufacture of uranium, as well as soldiers who are wounded with uranium shrapnel. The authors evaluated the effect of an internal source of an insoluble form of uranium on bone. Uranium dioxide powder (0.125 gm/kg body weight) was implanted subcutaneously in rats. After 30 days, animals exposed to uranium weighed less than controls. Bone formation activity in endochondral ossification and bone growth were also lower in the experimental animals, as evidenced by histomorphometric and morphometric methods. This is the first study to report bone damage resulting from continuous, nonlethal exposure to an insoluble compound of uranium dioxide over a period of 30 days.