Prospective study evaluating olfactometric and rhinomanometric outcomes in postmenopausal women on 1 mg 17β-estradiol and 2 mg drospirenone HT
Prospective study evaluating olfactometric and rhinomanometric outcomes in postmenopausal women on 1 mg 17β-estradiol and 2 mg drospirenone HT
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DOI：
10.1097/gme.0b013e31816be973
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发表时间：
2008-09-01
影响因子：
2.7
通讯作者：
Cianci, Antonio
中科院分区：
文献类型：
--
作者：
Caruso, Salvatore;Serra, Agostino;Cianci, Antonio
目的：评价屈螺酮油对绝经后激素治疗（HT）妇女嗅觉敏感性的影响。设计：47名自然绝经后妇女参与前瞻性研究。这些妇女持续接受含有1毫克17 -雌二醇和2毫克屈螺酮（DRSP）的联合治疗。气流阻力值和嗅觉阈值分别在基线和第三和第六个HT周期使用鼻测法和嗅觉测法测量。结果：与基线时相比，17 β -雌二醇/DRSP HT期间鼻测值更好（P < 0.001）。嗅觉阈值数据显示，在17 β -雌二醇/DRSP HT的第三周期（P < 0.05）和第六周期（P < 0.001）中，敏感性均高于基线。结论：我们的研究证实鼻腔气流阻力和嗅觉阈值可能与类固醇激素有关。我们认为雌激素可能影响嗅觉系统神经元的可塑性和神经传导时间。DRSP的抗矿化皮质激素活性可能减少鼻水肿，诱导气味物质与受体之间更好的相互作用。
Objective: To evaluate the effects of drospirenone oil the olfactory sensitivity in postmenopausal women treated with hormone therapy (HT).Design: Forty-seven naturally postmenopausal women participated in the prospective study. The women Underwent continuous combined HT containing 1 mg 17 beta-estradiol and 2 mg drospirenone (DRSP). Airflow resistance values and olfactometric thresholds were measured by using rhinomanomety and olfactometry, respectively, performed at baseline and in the third and sixth cycle of HT.Results: Rhinomanometric values were better during 17 beta-estradiol/DRSP HT with respect to those observed at baseline (P < 0.001). Olfactometric threshold data indicated a higher sensitivity during both the third (P < 0.05), and sixth cycles of 17 beta-estradiol/DRSP HT (P < 0.001) than at baseline.Conclusions: Our study confirmed that the nasal airflow resistance and olfactory thresholds to odors may depend on steroid hormones. We believe that estrogens could influence neuronal plasticity and the neuronal conduction time in the olfactory system. The antimineralocorticoid activity of DRSP may produce a decrease in nasal edema, inducing a better interaction between odorous substances with receptors.