H2S serves as the immunoregulatory essence of apoptotic cell death.
H2S serves as the immunoregulatory essence of apoptotic cell death.
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H2S是细胞凋亡的免疫调节本质。
DOI：
10.1016/j.cmet.2023.12.006
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发表时间：
2024
期刊：
影响因子：
29
通讯作者：
Martín-Montalvo,Alejandro
中科院分区：
文献类型：
--
作者：
Hine,Christopher;Ponti,AndrásK;Cáliz-Molina,MaríaÁngeles;Martín-Montalvo,Alejandro
细胞凋亡通过清除受损和功能异常的细胞来支持组织稳态并预防免疫紊乱。在这里，Ou et al.利用遗传学、药理学和蛋白质组学方法，重点研究硫氨基酸催化剂，发现细胞凋亡过程中硫化氢（H2S）释放抑制Th17细胞分化，从而为自身免疫性疾病提供治疗靶点。
Apoptosis supports tissue homeostasis and prevents immune disorders by removing damaged and functionally aberrant cells. Here, Ou et al. utilized genetic, pharmacological, and proteomic approaches focused on sulfur amino acid catabolism to discover that hydrogen sulfide (H2S) release during apoptosis suppresses Th17 cell differentiation, thus providing therapeutic targets for autoimmune diseases.