Are BPI and BPII suicide attempters distinct neuropsychologically?
Are BPI and BPII suicide attempters distinct neuropsychologically?
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DOI：
10.1016/j.jad.2006.04.010
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发表时间：
2006-08-01
影响因子：
6.6
通讯作者：
Oquendo, Maria
中科院分区：
文献类型：
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作者：
Harkavy-Friedman, Jill M.;Keilp, John G.;Oquendo, Maria
目前尚不清楚双相情感障碍I型（BPI）和双相情感障碍II型（BPII）是否代表严重程度连续的相同障碍或两种不同的综合征。神经心理功能是了解诊断组之间的异同的一种手段。目的：比较抑郁症自杀者与BPI或BPII和健康对照组的神经心理功能。51名双相情感障碍患者（BPI n = 32，BPII n = 19）和自杀未遂史与58名健康对照者在以下领域的神经心理功能进行了比较：结果：BPI组和BPII组在数字符号测验、工作记忆测验和Go-No-Go冲动测验中的成绩均显著低于健康对照组。在语言流畅性测试中，BPI组的表现明显差于对照组，但BPI组的表现并不差于对照组。参与者与BPII的表现显着差于任何控制或BPI的简单反应时间运动测试和Stroop测试attention.Conclusion：虽然参与者与BPI和BPII的表现比健康对照组更差，个人与BPII也比那些与BPI的一些测试表明，他们可能有一个独特的综合征表现更差。这一发现对双相情感障碍的评估和治疗具有重要意义。(c)2006 Elsevier B. V.保留所有权利。
It is not clear if bipolar disorder I (BPI) and bipolar disorder II (BPII) represent the same disorder on a continuum of severity or two distinct syndromes. Neuropsychological functioning is a means of understanding similarities and differences between diagnostic groups.Objective: To compare the neuropsychological functioning of depressed suicide attempters with BPI or BPII and healthy controls.Methods: Fifty-one individuals with bipolar disorder (BPI n = 32, BPII n = 19) and a history of suicide attempt were compared with 58 healthy controls with respect to neuropsychological functioning in the following domains: motor functioning, psychomotor performance, attention, memory, working memory, impulsiveness and language fluency.Results: Participants with BPI and BPII performed significantly more poorly than healthy controls on tests of Digit Symbol Test of psychomotor functioning, the N Back Test of working memory and the Go-No-Go Test of impulsiveness. Participants with BPI were significantly worse than controls but not those with BPII on the Test of Verbal Fluency. Participants with BPII performed significantly worse than either controls or those with BPI on the Simple Reaction Time Motor Test and the Stroop Test of attention.Conclusion: While participants with both BPI and BPII performed more poorly than healthy controls, individuals with BPII also performed more poorly than those with BPI on some tests suggesting that they may have a unique syndrome. The findings have implications for assessment and treatment in bipolar disorder. (c) 2006 Elsevier B.V. All rights reserved.