Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.
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DOI：
10.1016/j.cbpa.2010.02.001
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发表时间：
2010-06
影响因子：
7.8
通讯作者：
Tan, Derek S.
中科院分区：
文献类型：
--
作者：
Bauer, Renato A.;Wurst, Jacqueline M.;Tan, Derek S.
现有药物针对的生物靶点范围相对狭窄。因此，药物样分子库已被证明对各种具有挑战性的靶标无效，如蛋白质-蛋白质相互作用、核酸复合物和抗菌形式。相比之下，已知天然产物在调节这些靶标方面是有效的，并且基于与天然产物相关的未被充分代表的支架和化学空间区域正在开发新的文库。这导致了最近在确定解决这些具有挑战性的目标的新化学探针方面的几项成功。
Existing drugs address a relatively narrow range of biological targets. As a result, libraries of drug-like molecules have proven ineffective against a variety of challenging targets, such as protein–protein interactions, nucleic acid complexes, and antibacterial modalities. In contrast, natural products are known to be effective at modulating such targets, and new libraries are being developed based on underrepresented scaffolds and regions of chemical space associated with natural products. This has led to several recent successes in identifying new chemical probes that address these challenging targets.
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影响因子：
8
作者：
Ni Chonghaile T;Letai A
通讯作者：
Letai A
DOI：
10.1126/science.1176667
发表时间：
2009-08-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fischbach MA;Walsh CT
通讯作者：
Walsh CT
影响因子：
5.6
作者：
Fink, Tobias;Reymond, Jean-Louis
通讯作者：
Reymond, Jean-Louis
DOI：
10.1021/ci0200467
发表时间：
2003-01-01
期刊：
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
影响因子：
--
作者：
Feher, M;Schmidt, JM
通讯作者：
Schmidt, JM
影响因子：
14.8
作者：
Hert, Jerome;Irwin, John J.;Laggner, Christian;Keiser, Michael J.;Shoichet, Brian K.
通讯作者：
Shoichet, Brian K.