Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT7 receptors in rats
Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT7 receptors in rats
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DOI：
10.1111/bph.13941
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发表时间：
2017-09
影响因子：
7.3
通讯作者：
Takahiro Shimizu;Shogo Shimizu;N. Wada;S. Takai;Nobutaka Shimizu;Y. Higashi;K. Kadekawa;T. Majima;M. Saito;N. Yoshimura
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文献类型：
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作者：
Takahiro Shimizu;Shogo Shimizu;N. Wada;S. Takai;Nobutaka Shimizu;Y. Higashi;K. Kadekawa;T. Majima;M. Saito;N. Yoshimura
心理压力会加剧膀胱功能障碍的症状；然而，潜在的大脑机制尚不清楚。我们已经证明，中枢给予蛙皮素（一种与压力相关的神经肽）会促进大鼠的排尿反射。在压力条件下，脑内蛙皮素样肽调节5 - 羟色胺能神经系统的活动；因此，我们研究了在氨基甲酸乙酯麻醉的雄性Sprague - Dawley大鼠中，脑内5 - 羟色胺是否参与蛙皮素诱导的排尿频率增加。
Psychological stress exacerbates symptoms of urinary bladder dysfunction; however, the underlying brain mechanisms are unclear. We have demonstrated that centrally administered bombesin, a stress‐related neuropeptide, facilitates the rat micturition reflex. Brain bombesin‐like peptides modulate the serotoninergic nervous system activity under stress conditions; therefore, we examined whether brain 5‐HT is involved in the bombesin‐induced increased frequency of urination in urethane‐anaesthetised male Sprague–Dawley rats.