Monoaminergic modulation of decision-making under risk of punishment in a rat model.
Monoaminergic modulation of decision-making under risk of punishment in a rat model.
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DOI：
10.1097/fbp.0000000000000448
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发表时间：
2018-12
影响因子：
1.6
通讯作者：
Setlow B
中科院分区：
文献类型：
--
作者：
Blaes SL;Orsini CA;Mitchell MR;Spurrell MS;Betzhold SM;Vera K;Bizon JL;Setlow B
在风险和回报各不相同的选择中做出有利决定的能力对生存和幸福至关重要。先前的研究表明，某些形式的风险决策是由单胺信号稳健地调节的，但单胺信号如何调节明确惩罚风险下的决策尚不清楚。这些实验的目的是确定这种形式的决策是如何被多巴胺、血清素和去甲肾上腺素信号调节的，通过一项任务，让老鼠在小的、“安全的”食物奖励和与惩罚风险相关的大食物奖励之间做出选择。通过使用D2/3多巴胺受体激动剂（溴隐亭）和选择性D2激动剂（苏马尼罗），降低了对大的、有风险的奖励（冒险）的偏好。选择性D3激动剂PD128907似乎减弱了奖励辨别能力，但不影响风险承担本身。相反，针对血清素能和去甲肾上腺素能信号的药物对选择行为几乎没有影响。这些数据表明，与其他形式的风险决策相比，在惩罚风险下的决策是由多巴胺信号选择性调节的，主要是通过D2受体。
The ability to decide advantageously among options that vary in both their risks and rewards is critical for survival and well-being. Previous work shows that some forms of risky decision making are robustly modulated by monoamine signaling, but it is less clear how monoamine signaling modulates decision making under risk of explicit punishment. The goal of these experiments was to determine how this form of decision making is modulated by dopamine, serotonin, and norepinephrine signaling, using a task in which rats choose between small, “safe” food rewards and large food rewards associated with variable risks of punishment. Preference for the large, risky reward (risk taking) was reduced by administration of a D2/3 dopamine receptor agonist (bromocriptine) and a selective D2 agonist (sumanirole). The selective D3 agonist PD128907 appeared to attenuate reward discrimination abilities, but did not affect risk taking per se. In contrast, drugs targeting serotonergic and noradrenergic signaling had few if any effects on choice behavior. These data suggest that in contrast to other forms of risky decision making, decision making under risk of punishment is selectively modulated by dopamine signaling, predominantly through D2 receptors.