THE MEASUREMENT AND MECHANISM OF LIPID-PEROXIDATION IN BIOLOGICAL-SYSTEMS
THE MEASUREMENT AND MECHANISM OF LIPID-PEROXIDATION IN BIOLOGICAL-SYSTEMS
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DOI：
10.1016/0968-0004(90)90206-q
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发表时间：
1990-04-01
影响因子：
13.8
通讯作者：
HALLIWELL, B
中科院分区：
文献类型：
--
作者：
GUTTERIDGE, JMC;HALLIWELL, B
脂质过氧化反应传播的基本化学原理多年来已为人所知，但生物膜系统中这一过程的启动机制仍不确定。回顾了目前可用的测量过氧化的测定方法——所使用的测定方法越具体，健康人体组织和体液中发现的过氧化物就越少。在许多疾病状态下，脂质过氧化可能是组织损伤的结果，有时可能会显着加剧组织损伤。
The basic chemistry of the propagation of lipid peroxidation reactions has been known for years, but the mechanism of initiation of this process in biological membrane systems is still uncertain. Currently available assays for measuring peroxidation are reviewed - the more specific the assay used, the less peroxide is found in healthy human tissues and body fluids. Lipid peroxidation can arise as a consequence of tissue injury in many disease states and may sometimes contribute significantly to worsening the tissue injury.