The spontaneously hypertensive rat Y chromosome produces an early testosterone rise in normotensive rats
The spontaneously hypertensive rat Y chromosome produces an early testosterone rise in normotensive rats
复制标题
自发性高血压大鼠 Y 染色体导致正常血压大鼠早期睾酮升高
DOI：
10.1097/00004872-199407000-00007
复制
发表时间：
1994
影响因子：
4.9
通讯作者：
M. Turner
中科院分区：
文献类型：
--
作者：
D. Ely;Jessica Falvo;G. Dunphy;A. Caplea;R. Salisbury;M. Turner
Objective To investigate the relationship between testosterone and blood pressure during the rapid development phase of blood pressure rise in four strains of rats: Wistar–Kyoto (WKY) rats; spontaneously hypertensive rats (SHR); SHR/y, a substrain with an SHR Y chromosome and WKY rat autosomes and X chromosomes; and SHR/a, a substrain with SHR autosomes and X chromosomes and the WKY rat Y chromosome. Methods Blood pressure was measured every 2 weeks by the tail-cuff method, and was verified in selected rats at 23 weeks by aortic telemetry. Serum testosterone was measured, by radioimmunoassay, every 2 weeks from 5 to 23 weeks of age. Results During the rapid phase of blood pressure rise, between 5 and 9 weeks of age, there was a significantly larger rise in serum testosterone in SHR and SHR/y than in WKY rats and SHR/a groups. The hypertensive Y chromosome in the SHR and SHR/y accelerated peak testosterone approximately 4 weeks earlier, and blood pressure was increased in these two groups compared with the SHR/a and WKY rat groups, respectively. A gene on the SHR Y chromosome (Tty) affecting the timing of testosterone in development is proposed. At approximately 15 weeks of age testosterone levels decreased sharply towards prepubertal levels in WKY rats and at 23 weeks in SHR/y, whereas testosterone levels were maintained in SHR and SHR/a, which suggests an autosomal component. Conclusion The SHR Y chromosome may accelerate the start of puberty and a cascade of molecular and neuroendocrine events that raise blood pressure.
