Elastomeric biodegradable polyurethane blends for soft tissue applications
Elastomeric biodegradable polyurethane blends for soft tissue applications
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DOI：
10.1163/156856202320253929
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发表时间：
2002-01-01
影响因子：
3.6
通讯作者：
Woodhouse, KA
中科院分区：
文献类型：
--
作者：
Fromstein, JD;Woodhouse, KA
四种可生物降解聚氨酯共混物由含有氨基酸基扩链剂和二异氰酸酯基团的分段聚氨酯制成。这些母体聚氨酯的软段是聚环氧乙烷（PEO）或聚己内酯（PCL）二醇。开发共混物是为了研究不同软段成分对材料整体形态、机械和降解性能的影响，以期生产一系列具有广泛性能的材料。加入高度亲水性的PEO材料以增加共混物的降解敏感性，而选择PCL聚氨酯以提供比PEO母材更高的模量和伸长率（应变）。所有四种共混物都被确定为半结晶的弹性体材料，具有与聚氯乙烯基母聚氨酯相似的应力-应变曲线。随着共混物中PEO聚氨酯成分百分比的增加，材料变得更弱，更不容易拉伸。共混物在缓冲液中表现出快速的初始降解，随后是明显较慢的长期降解，可能与主要含peo的聚合物的初始损失相对应，随后是PCL聚氨酯的较慢降解。所有四种共混物都成功地利用溶剂铸造/颗粒浸出方法形成三维多孔支架。由于这些新的混合物具有一系列的机械和降解性能，并且可以塑造成三维物体，这些材料可能在软组织工程支架应用中具有潜在的用途。
Four biodegradable polyurethane blends were made from segmented polyurethanes that contain amino acid-based chain extender and diisocyanate, groups. The soft segments of these parent polyurethanes were either polyethylene oxide (PEO) or polycaprolactone (PCL) diols. The blends were developed to investigate the effect of varying soft segment compositions on the overall morphological, mechanical, and degradative properties of the materials, with a view to producing a family of materials with a wide range of properties. The highly hydrophilic PEO material was incorporated to increase the blend's susceptibility to degradation, while the PCL polyurethane was selected to provide higher moduli and percent elongations (strains) than the PEO parent materials can achieve. All four blends were determined to be semi-crystalline, elastomeric materials that possess similarly shaped stress-strain curves to that of the PCL-based parent polyurethane. As the percent composition of PEO polyurethane within the blend increased, the material became weaker and less extensible. The blends demonstrated rapid initial degradation in buffer followed by significantly slower, prolonged degradation, likely corresponding to an initial loss of primarily PEO-containing polymer, followed by the slower degradation of the PCL polyurethane. All four blends were successfully formed into three-dimensional porous scaffolds utilizing solvent casting/particulate leaching methods. Since these new blends possess a range of mechanical and degradation properties and can be shaped into three-dimensional objects, these materials may hold potential for use in soft tissue engineering scaffold applications.