Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration.
Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration.
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DOI：
10.1007/s11886-017-0826-1
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发表时间：
2017-02
影响因子：
3.7
通讯作者：
Kühn B
中科院分区：
文献类型：
--
作者：
Yester JW;Kühn B
先天性心脏病是最常见的出生缺陷，后天性心脏病是成人死亡的主要原因。了解驱动心肌细胞增殖和分化的机制有可能促进对不同心脏病理的理解和治疗，从肌病，心力衰竭到心肌梗死。本文综述了促进分化心肌细胞增殖、分化和再生的信号转导途径和分子机制。现在有重要的证据表明，心肌细胞继续增殖到成年期。已经鉴定了潜在的调节剂，包括细胞周期调节剂、细胞外配体如神经调节蛋白、表观遗传靶点、活性氧和微小RNA。必要的步骤应该包括验证和应用有关心肌细胞再生的新知识，以开发患者的治疗靶点。这将通过应用标准化的临床前模型来研究心肌细胞再生来促进。
Congenital heart disease is the most common birth defect and acquired heart disease is the leading cause of death in adults. Understanding the mechanisms that drive cardiomyocyte proliferation and differentiation has the potential to advance the understanding and potentially the treatment of different cardiac pathologies, ranging from myopathies, heart failure, to myocardial infarction. This review focuses on studies aimed at elucidating signal transduction pathways and molecular mechanisms that promote proliferation, differentiation, and regeneration of differentiated heart muscle cells, cardiomyocytes. There is now significant evidence that demonstrates cardiomyocytes continue to proliferate into adulthood. Potential regulators have been identified, including cell cycle regulators, extracellular ligands such as neuregulin, epigenetic targets, reactive oxygen species, and micro RNA. The necessary steps should involve validating and applying the new knowledge about cardiomyocyte regeneration towards the development of therapeutic targets for patients. This will be facilitated by the application of standardized pre-clinical models to study cardiomyocyte regeneration.