Diffuse anterior retinoblastoma without retinal involvement.
Diffuse anterior retinoblastoma without retinal involvement.
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弥漫性前部视网膜母细胞瘤，无视网膜受累。
DOI：
10.1016/j.ophtha.2010.02.010
复制
发表时间：
2010
期刊：
影响因子：
13.7
通讯作者：
H. Boldt
中科院分区：
文献类型：
--
作者：
Susannah Q. Longmuir;Nasreen A. Syed;H. Boldt
本文报告一例8.5岁儿童单侧前部假性输尿管炎的独特病例。他被发现有单侧，侵袭性，小蓝细胞肿瘤的眼前段，被诊断为弥漫性浸润性视网膜母细胞瘤，尽管缺乏视网膜参与眼底检查或组织病理学分析。患者接受前房液细针穿刺活检（FNAB），结果与原始神经外胚层肿瘤一致，无论是视网膜母细胞瘤还是髓上皮瘤。视网膜母细胞瘤是有利的强烈，病人接受了眼球摘除术，然后用长春新碱，卡铂和依托泊苷进行化疗，并对眼窝进行了4140 cGy的放射治疗。主要结果测量病人存活，随访5年无肿瘤。显微镜检查显示与FNAB上所见细胞相似的细胞浸润虹膜基质，小梁网，施累姆氏管，和巩膜的内部在角的区域中。未发现钙化。连续切片的整个地球仪进行，以确定肿瘤的起源。未发现视网膜受累，也未发现睫状体上皮发生肿瘤。免疫组化显示突触素阳性，白细胞共同抗原和CD 34阴性。结论该患者为弥漫性前部视网膜母细胞瘤，视网膜无明显受累。病理分析未发现髓上皮瘤的典型形态特征。虽然患者缺乏视网膜病灶，但他存活了5年，没有肿瘤复发的证据。财务披露：作者在本文中讨论的任何材料中没有专有或商业利益。
PURPOSETo present a unique case of an 8.5-year-old child with unilateral, anterior, pseudouveitis. He was found to have unilateral, invasive, small blue cell tumor of the anterior segment that was diagnosed as diffuse infiltrating retinoblastoma despite lack of retinal involvement on fundus examination or histopathologic analysis.DESIGNInterventional case report.PARTICIPANTSOne patient.INTERVENTIONThe patient was treated with topical prednisolone acetate 1% and oral prednisone with no improvement in anterior chamber reaction. The patient underwent fine-needle aspiration biopsy (FNAB) of anterior chamber fluid, the results of which were consistent with a primitive neuroectodermal neoplasm, either retinoblastoma or medulloepithelioma. Retinoblastoma was favored strongly, and the patient underwent enucleation followed by chemotherapy with vincristine, carboplatin, and etoposide, and radiation to the eye socket of 4140 cGy total was performed.MAIN OUTCOME MEASURESThe patient is alive and tumor free with follow-up of 5 years.RESULTSMicroscopic examination demonstrated cells similar to those seen on the FNAB infiltrating the iris stroma, trabecular meshwork, Schlemm's canal, and the inner portion of sclera in the region of the angle. No calcifications were identified. Serial sections of the entire globe were performed to determine the origin of the tumor. No retinal involvement was identified, and tumor was not seen to arise from the ciliary epithelium. Immunohistochemistry demonstrated positive staining with synaptophysin and negative staining with leukocyte common antigen and CD34.CONCLUSIONSThis patient represents a case of diffuse anterior retinoblastoma with lack of obvious retinal involvement. Morphologic features typical of medulloepithelioma were not found on pathologic analysis. Although the patient lacked a retinal focus, he is alive at 5 years without evidence of recurrence of tumor. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
影响因子：
--
作者：
M. Uusitalo;K. V. Quill;Ingrid U. Scott;K. Matthay;Timothy G. Murray;Joan M. O'Brien
通讯作者：
M. Uusitalo;K. V. Quill;Ingrid U. Scott;K. Matthay;Timothy G. Murray;Joan M. O'Brien
眼内髓质上皮瘤中的感光细胞分化：一项免疫组织病理学研究。
DOI：
10.1001/archopht.1990.01070060029013
发表时间：
1990
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Desai,VN;Lieb,WE;Donoso,LA;EagleJr,RC;Shields,JA;Saunders,R
通讯作者：
Saunders,R
前部弥漫性视网膜母细胞瘤：突变分析和免疫荧光染色。
影响因子：
4.6
作者：
Crosby,MichelleB;Hubbard,GBaker;Gallie,BrendaL;Grossniklaus,HansE
通讯作者：
Grossniklaus,HansE