Causal relationships between mood instability and autoimmune diseases: A mendelian randomization analysis
Causal relationships between mood instability and autoimmune diseases: A mendelian randomization analysis
复制标题
情绪不稳定与自身免疫性疾病之间的因果关系：孟德尔随机分析
DOI：
10.1016/j.autrev.2022.103214
复制
发表时间：
2022
影响因子：
13.6
通讯作者：
Chongbo Zhao
中科院分区：
文献类型：
--
作者：
Huahua Zhong;Xiao Huan;Kexin Jiao;Shen He;Zhu Wen;Rui Zhao;Li-Ying Goh;Manqiqige Su;Jie Song;Chong Yan;Jianying Xi;Xueying Zheng;Zhirui Zhou;Sushan Luo;Chongbo Zhao
目的近年来，心理健康与自身免疫的相互关系越来越受到重视。然而，人格特质和自身免疫性疾病之间的因果关系仍然在很大程度上unknown.MethodsWe首先进行了两个样本孟德尔随机化（MR）分析情绪不稳定，这是一个常见的人格特质，在一般人群中，和10自身免疫性疾病之间的关系。结果进一步验证了在不同的MR方法，种族，性别和ascertainment methods.ResultsIn主要分析的敏感性二次分析，三种自身免疫性疾病表现出遗传易感性情绪不稳定：哮喘（OR [95%CI] = 3.45 [2.48，4.78]，P= 1.33E- 13），甲状腺功能减退（OR [95%CI] = 1.02 [1.00，1.03]，P= 1.71E-02）和系统性红斑狼疮（OR [95%CI] = 5.25 [1.21，22.76]，P= 2.67E-02）。在随后的次要分析中，结果一致。三种疾病仍然显着相关的情绪不稳定，不同的MR方法与哮喘仍然显着的芬兰和混合人群，并在女性从英国biobank.ConclusionMood不稳定是一个可修改的危险因素，包括哮喘，甲状腺功能减退症和系统性红斑狼疮三种自身免疫性疾病，在英国biobank.ConclusionMood不稳定。
ObjectivesThe interrelationship between mental health and autoimmunity gains more and more attention in recent years. However, the causality between personality traits and autoimmune diseases remained largely unknown.MethodsWe first conducted two-sample mendelian randomization (MR) analysis on the relationships between mood instability, which is a common personality trait in the general population, and 10 autoimmune diseases. The results were further validated in secondary analyses of sensitivity where different MR methods, ethnicities, genders, and ascertainment methods were compared.ResultsIn the primary analyses, three autoimmune diseases showed genetical predisposition to mood instability: asthma (OR [95%CI] = 3.45 [2.48, 4.78],P= 1.33E- 13), hypothyroidism (OR [95%CI] = 1.02 [1.00, 1.03],P= 1.71E-02), and systemic lupus erythematosus (OR [95%CI] = 5.25 [1.21, 22.76],P= 2.67E-02). The results were consistent in subsequent secondary analyses. Three diseases remained significantly correlated with mood instability by different MR methods with asthma remaining significant in Finnish and mixed populations, and in females from the UK biobank, while hypothyroidism remained significant in both genders from the UK biobank.ConclusionMood instability is a modifiable risk factor for three autoimmune diseases including asthma, hypothyroidism and systemic lupus erythematosus.