P53R2, p53 inducible ribonucleotide reductase gene, correlated with tumor progression of non-small cell lung cancer.
P53R2, p53 inducible ribonucleotide reductase gene, correlated with tumor progression of non-small cell lung cancer.
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发表时间：
2006-03
影响因子：
2
通讯作者：
H. Uramoto;K. Sugio;T. Oyama;T. Hanagiri;K. Yasumoto
中科院分区：
文献类型：
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作者：
H. Uramoto;K. Sugio;T. Oyama;T. Hanagiri;K. Yasumoto
p53R2在提供DNA修复的dNTPs中起着至关重要的作用。DNA损伤剂诱导p53R2以依赖p53的方式表达，DNA损伤后p53R2易位到细胞核。采用免疫组化方法分析130例特征明确的非小细胞肺癌（NSCLC）石蜡包埋肿瘤标本中p53R2的蛋白表达，比较p53R2的表达水平、临床变量和生存结局。在130例非小细胞肺癌患者中，61例（46.2%）肿瘤细胞细胞质中检测到p53R2阳性表达。病理分期II/III期、病理T3-4期、病理N1-3期的阳性率分别显著高于I期、T1-2期和N0期。p53R2表达与性别、手术年龄、组织学类型及p53表达无显著差异。虽然我们的研究结果不支持p53R2免疫细胞化学标记物单独在非小细胞肺癌中发挥重要的预后作用，但p53R2介导的DNA修复途径可能负责控制肺癌的生长。
p53R2 plays a crucial role in supplying dNTPs for DNA repair. The expression of p53R2 is induced by DNA-damaging agents in a p53-dependent manner and p53R2 translocates to the nucleus upon DNA damage. Immunohistochemistry was used to analyze the protein expression of p53R2 in paraffin-embedded tumor samples from 130 well-characterized non-small cell lung cancer (NSCLC) patients and the expression level of p53R2, clinical variables and survival outcome were compared. A positive expression of p53R2 was detected in the cytoplasm of tumor cells in 61 of the 130 patients (46.2%) with NSCLC. The positive ratio was significantly higher in the patients with pathological stage II/III, pathological T3-4 and pathological N1-3 than in those with stage I, T1-2 and N0, respectively. No significant difference was observed between the p53R2 expression and the gender, age at operation, histological type or p53 expression. Though our findings do not support that the p53R2 immunocytochemical marker alone plays an important prognostic role in NSCLC, the DNA repair pathway mediated by p53R2 may be responsible for controlling the growth of lung cancer.