microRNA: human disease and development.
microRNA: human disease and development.
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DOI：
10.1504/ijbra.2009.028678
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Parundekar, Akshay N
中科院分区：
文献类型：
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作者：
Gomase, Virendra S;Parundekar, Akshay N
microRNA或miRNAs是一类丰富的高度转化的小的非编码RNA，其呈现了转录后基因调控的全新主题。miRNAs在病毒学、胚胎发生、分化、炎症和癌症研究等多种生物学系统中发挥着关键作用。研究表明这些非编码小RNA对免疫系统发育和反应的重要性。它在大多数真核生物的多种代谢途径中起着重要的调节作用。miRNAs被发现参与免疫调节，包括免疫细胞的发育和分化、抗体的产生和炎症介质的释放。
microRNAs or miRNAs are an abundant class of highly conversed, small non-coding RNAs that present an entirely new theme of post-transcriptional gene regulation. miRNAs play a key role in diverse biological systems, such as virology, embryogenesis, differentiation, inflammation and cancer research. Research showed the importance of these non-coding small RNAs on immune system development and response. It plays important regulatory roles in various metabolic pathways in most eukaryotes. miRNAs are found to be involved in the regulation of immunity, including the development and differentiation of immune cells, antibody production and the inflammatory mediator release.