Translational Control of Gene Expression , edited by Nahum Sonenberg, John W.B. Hershey, and Michael B. Mathews. 2000. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. Cloth, 1,020 pp. $113.
Translational Control of Gene Expression , edited by Nahum Sonenberg, John W.B. Hershey, and Michael B. Mathews. 2000. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. Cloth, 1,020 pp. $113.
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基因表达的翻译控制，由 Nahum Sonenberg、John W.B. 编辑
DOI：
10.1017/s1355838201002540
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发表时间：
2001
期刊：
影响因子：
4.5
通讯作者：
N. Standart
中科院分区：
文献类型：
--
作者：
V. M. Pain;N. Standart
二十年来，直到 20 世纪 80 年代中期，基因表达翻译阶段的研究都是由一小部分蛋白质生物化学、细胞生理学和发育生物学实验室进行的。这些工作人员反对一种广泛持有的观点，即基因表达控制中任何令人兴奋的事情都必须发生在转录水平上。然而，从那时起，分子遗传学的应用揭示了一系列令人惊奇的机制，用于调节整体蛋白质合成和选择性控制单个 mRNA 的翻译以响应生理条件。这导致大量工作人员涌入该领域，在 1987 年召开的每两年一次的翻译控制会议期间，对冷泉港实验室的餐饮设施提出了严峻的挑战。第一本冷泉港“翻译控制”专着于 1996 年出版，其优秀文章为资深工作人员和新来者提供了宝贵的资源。然而，这本书现在看起来显然已经是中年了，这反映了这一领域知识的快速发展。因此，决定在2000年出版新的文章集。虽然新专着的36章中有一些是对以前涵盖的主题的必要更新，但到目前为止，大多数文章是由不同的作者撰写的，涵盖了新的方向，其中许多在1996年还算不上什么。
For two decades, up to the mid-1980s, study of the translation phase of gene expression was conducted by a relatively small group of protein biochemistry, cell physiology, and developmental biology labs. These workers labored against a widely held view that anything and everything exciting in the control of gene expression must occur at the level of transcription. Since that time, however, the use of molecular genetics has revealed an amazing array of mechanisms for regulating both overall protein synthesis and selective control of translation of individual mRNAs in response to physiological conditions. This led to a remarkable influx of workers into the field, severely challenging the catering facilities at the Cold Spring Harbor Laboratory during the biannual meetings on Translational Control, which were inaugurated in 1987. The first Cold Spring Harbor “Translational Control” monograph was published in 1996, and its excellent articles have provided a valuable resource to established workers and newcomers alike. However, it is a reflection of the rapid development of knowledge in this field that this volume now looks decidedly middle-aged. It was therefore decided to produce a new volume of articles for the year 2000. Although a few of the 36 chapters in the new monograph are necessary updates of subjects covered previously, by far the majority of the articles are by different authors and cover new directions, many of which were barely a gleam in the eye in 1996.