Improved cortical bone specificity in UTE MR Imaging.
Improved cortical bone specificity in UTE MR Imaging.
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DOI：
10.1002/mrm.26160
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发表时间：
2017-02
影响因子：
3.3
通讯作者：
Pauly, John M.
中科院分区：
文献类型：
--
作者：
Johnson, Ethan M.;Vyas, Urvi;Ghanouni, Pejman;Pauly, Kim Butts;Pauly, John M.
关键词：
用于使用MRI直接可视化密质骨的方法已经应用于若干“MR知情”技术，诸如MR引导的聚焦超声、MR-PET重建和MR引导的放射治疗。骨成像的特异性可以通过操纵图像对布洛赫弛豫现象的灵敏度来提高，从而促进通过MRI检测的骨与其他组织的区分。从布洛赫方程动力学，激励脉冲适合于创建特定的敏感性，从皮质骨短T2磁化。这些脉冲与UTE减影一起使用，证明了具有正对比度的密质骨MR成像的可行性。骨结构的MR图像以与在X射线CT图像中观察到的类似的对比度来采集。通过比较头颅MR信号强度与CT Hounsfield单位，量化对比度的相似性。MR技术还在与介入手术相关的身体其他区域（如肩部、骨盆和腿部）中得到证实。将RF激励脉冲与弛豫率匹配可提高短T2对比度对骨的特异性。它被证明与一个UTE序列，以获得图像的皮质骨与阳性对比度，并验证对比度与X线CT。
Methods for direct visualization of compact bone using MRI have application in several ‘MR-informed’ technologies, such as MR-guided focused ultrasound, MR-PET reconstruction and MR-guided radiation therapy. The specificity of bone imaging can be improved by manipulating image sensitivity to Bloch relaxation phenomena, facilitating distinction of bone from other tissues detected by MRI. From Bloch equation dynamics, excitation pulses suitable for creating specific sensitivity to short-T2 magnetization from cortical bone are identified. These pulses are used with UTE subtraction demonstrate feasibility of MR imaging of compact bone with positive contrast. MR images of bone structures are acquired with contrast similar to that observed in x-ray CT images. Through comparison of MR signal intensities with CT Hounsfield units of the skull, the similarity of contrast is quantified. The MR technique is also demonstrated in other regions of the body that are relevant for interventional procedures, such as the shoulder, pelvis and leg. Matching RF excitation pulses to relaxation rates improves the specificity to bone of short-T2 contrast. It is demonstrated with a UTE sequence to acquire images of cortical bone with positive contrast, and the contrast is verified by comparison with x-ray CT.
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