Defining the role of NK cells during dengue virus infection.
Defining the role of NK cells during dengue virus infection.
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定义 NK 细胞在登革热病毒感染过程中的作用。
DOI：
10.1111/imm.12928
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发表时间：
2018
期刊：
影响因子：
6.4
通讯作者：
Mathew,Anuja
中科院分区：
文献类型：
--
作者：
Mathew,Anuja
近年来，我们对自然杀伤细胞（NK）上存在的多种受体和靶细胞上存在的配体之间需要整合的复杂信号数量的理解有所提高。在这里，我们回顾了在鉴定HLA 1类分子上呈递的登革病毒肽与NK细胞上抑制和激活杀伤样免疫球蛋白受体之间的相互作用、病毒蛋白与NK细胞受体的直接相互作用、登革病毒特异性抗体参与介导抗体依赖细胞介导的细胞毒性以及可溶性因子在调节NK细胞反应中的作用方面的进展。我们讨论了自然登革热感染后早期NK细胞活化的发现，并指出NK细胞在调节先天和适应性免疫反应中可能发挥的作用，在我们对登革热病毒与特异性NK细胞受体相互作用的新认识的背景下。随着许多黄病毒候选疫苗进入临床试验，需要考虑NK细胞如何对减毒登革热病毒和亚单位蛋白候选疫苗作出反应并形成适应性免疫。
In recent years, our understanding of the complex number of signals that need to be integrated between a diverse number of receptors present on natural killer (NK) cells and ligands present on target cells has improved. Here, we review the progress made in identifying interactions between dengue viral peptides presented on HLA Class 1 molecules with inhibitory and activating killer‐like immunoglobulin receptors on NK cells, direct interactions of viral proteins with NK cell receptors, the involvement of dengue virus‐specific antibodies in mediating antibody‐dependent cell‐mediated cytotoxicity and the role of soluble factors in modulating NK cell responses. We discuss findings of NK cell activation early after natural dengue infection, and point to the role that NK cells may play in regulating both innate and adaptive immune responses, in the context of our new appreciation of interactions of dengue virus with specific NK cell receptors. With a number of flavivirus vaccine candidates in clinical trials, how NK cells respond to attenuated dengue virus and subunit protein vaccine candidates and shape adaptive immunity will need to be considered.