A stabilized formulation of IBX (SIBX) for safe oxidation reactions including a new oxidative demethylation of phenolic methyl aryl ethers
A stabilized formulation of IBX (SIBX) for safe oxidation reactions including a new oxidative demethylation of phenolic methyl aryl ethers
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DOI：
10.1021/ol0349965
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发表时间：
2003-08-07
期刊：
影响因子：
5.2
通讯作者：
Quideau, S
中科院分区：
文献类型：
--
作者：
Ozanne, A;Pouységu, L;Quideau, S
GraphicsSIBX 是 IBX 的非爆炸性配方，可作为各种标准有机溶剂（例如回流 EtOAc 和 THF）中的悬浮液使用，以将醇安全氧化成醛和酮。热THF的使用仅限于烯丙醇和苄醇的氧化。大多数产量与使用 IBX 或 DMIP 获得的产量相当。 SIBX 还可用于将 2-甲氧基芳醇氧化去甲基化为邻醌和儿茶酚。
graphicsSIBX is a nonexplosive formulation of IBX that can be used as a suspension in a variety of standard organic solvents such as refluxing EtOAc and THF to oxidize safely alcohols into aidehydes and ketones. The use of hot THF is limited to the oxidation of allylic and benzylic alcohols. Most yields are comparable to those obtained with IBX or DMIP. SIBX can also be used to perform oxygenative demethylation of 2-methoxyarenols into orthoquinones and catechols.