Testing life-history pleiotropy in Caenorhabditis elegans
Testing life-history pleiotropy in Caenorhabditis elegans
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DOI：
10.1111/j.0014-3820.2001.tb00828.x
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发表时间：
2001-09-01
期刊：
影响因子：
3.3
通讯作者：
Leroi, AM
中科院分区：
文献类型：
--
作者：
Knight, CG;Azevedo, RBR;Leroi, AM
许多生活史理论假设等位基因在自然群体中的分离会多效性地影响生活史性状。这一假设虽然合理，但很少得到直接验证。在这里，我们调查了两个性状之间的遗传关系，通常认为是连接的多效性：母亲的身体大小和生育能力。我们进行了数量性状位点（QTL）分析的两个分离的自由生活线虫秀丽隐杆线虫，并确定了两个身体大小和三个育性QTL。我们发现其中一个育性QTL与第IV染色体上的两个体长QTL共定位。然而，进一步的分析表明，这些QTL是遗传分离的。因此，没有五个身体大小或育性QTL在这里确定的检测性状显示出可检测的多效性。讨论了这些QTL的进化起源、可能的候选位点及其在生活史进化中的意义。
Much life-history theory assumes that alleles segregating in natural populations pleiotropically affect life-history traits. This assumption, while plausible, has rarely been tested directly. Here we investigate the genetic relationship between two traits often suggested to be connected by pleiotropy: maternal body size and fertility. We carry out a quantitative trait locus (QTL) analysis on two isolates of the free-living nematode Caenorhabditis elegans, and identify two body size and three fertility QTLs. We find that one of the fertility QTLs colocalizes with the two body size QTLs on Chromosome IV. Further analysis, however, shows that these QTLs are genetically separable. Thus, none of the five body size or fertility QTLs identified here shows detectable pleiotropy for the assayed traits. The evolutionary origin of these QTLs, possible candidate loci, and the significance for life-history evolution are discussed.