The evolution of brain activation during temporal processing
The evolution of brain activation during temporal processing
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DOI：
10.1038/85191
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发表时间：
2001-03-01
影响因子：
25
通讯作者：
Harrington, DL
中科院分区：
文献类型：
--
作者：
Rao, SM;Mayer, AR;Harrington, DL
时机对人类表现的许多方面都至关重要。为了更好地理解其神经基础，我们使用事件相关功能磁共振成像来检查与时间感知任务的不同组成部分相关的激活的时间过程。我们区分了与编码时间间隔相关的系统和与比较间隔和实现响应相关的系统。基底神经节的激活发生得早，并且与编码时间间隔唯一相关，而小脑激活展开得晚，这表明参与了除明确计时之外的过程。在右下顶叶皮层和双侧运动前皮层中观察到与时间间隔编码相关的早期皮层激活，表明这些系统参与注意力和时间间隔的临时维持。在比较时间间隔的过程中，右侧背外侧前额叶皮层出现了晚期激活。我们的研究结果说明了一个动态的网络皮层皮层下激活与不同的组成部分的时间信息处理。
Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related to comparing intervals and implementing a response. Activation in the basal ganglia occurred early, and was uniquely associated with encoding time intervals, whereas cerebellar activation unfolded late, suggesting an involvement in processes other than explicit timing. Early cortical activation associated with encoding of time intervals was observed in the right inferior parietal cortex and bilateral premotor cortex, implicating these systems in attention and temporary maintenance of intervals. Late activation in the right dorsolateral prefrontal cortex emerged during comparison of time intervals. Our results illustrate a dynamic network of cortical-subcortical activation associated with different components of temporal information processing.