Prediction of Veno-Occlusive Disease Using Biomarkers of Endothelial Injury
Prediction of Veno-Occlusive Disease Using Biomarkers of Endothelial Injury
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DOI：
10.1016/j.bbmt.2010.02.016
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发表时间：
2010-08-01
影响因子：
4.3
通讯作者：
Antin, Joseph H.
中科院分区：
文献类型：
--
作者：
Cutler, Corey;Kim, Haesook T.;Antin, Joseph H.
预测肝脏静脉闭塞性疾病（VOD）的发展仍然具有挑战性。我们假设清髓性异基因移植受者内皮损伤的生物标志物可以预测VOD的发生。我们在移植围术期每周评估4种生物标志物-血管性血友病因子（vWF）、血栓调节蛋白、E-选择素和可溶性细胞间粘附分子-1（sICAM-1），试图预测VOD。在接受西罗莫司治疗的患者中，VOD患者第1天vWF、血栓调节蛋白和sICAM-1水平显著高于非VOD患者（P
Predicting the development of veno-occlusive disease (VOD) of the liver remains challenging. We hypothesized that biomarkers of endothelial injury in myeloablative allogeneic transplantation recipients could predict VOD occurrence. We evaluated 4 biomarkers-von Willebrand Factor (vWF), thrombomodulin, E-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1)-weekly in the peritransplantation period in an attempt to predict VOD. In the patients who received sirolimus, vWF, thrombomodulin, and sICAM-1 levels were significantly elevated in patients with VOD compared with those without VOD on day - 1 (P