The relationship between molar incisor hypomineralization, dental caries, socioeconomic factors, and polymorphisms in the vitamin D receptor gene: a population-based study
The relationship between molar incisor hypomineralization, dental caries, socioeconomic factors, and polymorphisms in the vitamin D receptor gene: a population-based study
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DOI：
10.1007/s00784-020-03263-y
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发表时间：
2020-03-31
影响因子：
3.4
通讯作者：
Feltrin-Souza, Juliana
中科院分区：
文献类型：
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作者：
Fatturi, Aluhe Lopes;Menoncin, Bruna Leticia;Feltrin-Souza, Juliana
本横断面研究的目的是探讨维生素D受体（VDR）基因多态性是否会增加龋齿、磨牙切牙低矿化（MIH）和初级第二磨牙低矿化（HPSM）的患病率。材料与方法在巴西巴拉那州库里蒂巴市随机抽取731名8岁学童作为具有代表性的人群样本。MIH、HPSM和龋齿由四名校准的检查人员（kappa >.80）进行临床评估，分别采用欧洲儿科牙科学会（2003）标准、改良的牙釉质发育缺陷（DDE）指数和世界卫生组织（2013）的蛀牙、缺失或补牙（DMFT）指数。采用实时聚合酶链反应对VDR rs739837和rs2228570多态性进行基因分型。相关性分析采用泊松回归，具有稳健方差（α = 0.05）。结果儿童MIH的龋患病率较高（DMFT bb0.1, PR = 2.52，可信区间= 1.60 ~ 3.97,p . 1）
Objectives The purpose of this cross-sectional study was to investigate whether polymorphisms in vitamin D receptor (VDR) genes increase the prevalence of dental caries, molar incisor hypomineralization (MIH), and hypomineralized primary second molars (HPSM). Material and methods A representative population-based sample of 731 schoolchildren, 8 years of age, was randomly selected in Curitiba, Parana, Brazil. MIH, HPSM, and dental caries were clinically assessed by four calibrated examiners (kappa > 0.80) using European Academy of Pediatric Dentistry (2003) criteria, the modified Developmental Defects of Enamel (DDE) index, and the Decayed, Missing, or Filled Teeth (DMFT) index by the World Health Organization (2013), respectively. The VDR rs739837 and rs2228570 polymorphisms were genotyped using real-time polymerase chain reaction. Associations were analyzed by Poisson regression with robust variance (alpha = 0.05). Results Schoolchildren with MIH presented a higher prevalence of dental caries (DMFT > 1, PR = 2.52, confidence interval = 1.60-3.97, p