Innovation - Control of DNA replication and its potential clinical exploitation
Innovation - Control of DNA replication and its potential clinical exploitation
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DOI：
10.1038/nrc1548
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发表时间：
2005-02-01
影响因子：
78.5
通讯作者：
Coleman, N
中科院分区：
文献类型：
--
作者：
Gonzalez, MA;Tachibana, KK;Coleman, N
多种保守的机制将DNA复制限制在每个细胞周期一次。一个重要的控制水平集中在复制开始时复制前复合体的分层组装中，将微小染色体维持蛋白(MCM)的异六聚体环装载到染色质上。MCM及其调节因子在增殖过程中的重要作用使其有可能成为癌症检测和预后的常规临床应用的重要生物标志物。
Multiple conserved mechanisms limit DNA replication to once per cell cycle. One vital level of control focuses on the loading of the heterohexameric ring of minichromosome maintenance proteins (MCMs) onto chromatin in the hierarchical assembly of the pre-replication complex at origins of replication. An essential role in proliferation for MCMs and their regulators makes them potentially important biomarkers for routine clinical use in cancer detection and prognosis.