Contrast-enhanced MRI of tumors. Comparison of Gd-DTPA and a macromolecular agent.
Contrast-enhanced MRI of tumors. Comparison of Gd-DTPA and a macromolecular agent.
复制标题
肿瘤的对比增强 MRI。
DOI：
10.1097/00004424-198908000-00007
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发表时间：
1989
影响因子：
6.7
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Wikström,MG;Moseley,ME;White,DL;Dupon,JW;Winkelhake,JL;Kopplin,J;Brasch,RC
该研究的目的是确定使用小分子细胞外液对比增强剂 [Gd-DTPA] 或大分子制剂 [白蛋白-(Gd-DTPA) 20] 进行肿瘤对比增强的磁共振 (MR) 模式的潜在差异和优势，专为主要血管内生物分布而设计。在注射 Gd-DTPA [0.2 mmol/kg, n= 11] 或白蛋白-(Gd-DTPA) [O. 之前和之后 120 分钟内重复获得 25 只植入纤维肉瘤小鼠的 MR 图像。 0029 毫摩尔/千克，n= 14]。在组织学上，这种缺乏血管的肿瘤包含存活组织区域和非存活坏死组织区域。使用任一类型的造影剂，存活部分强烈增强，高达 152%，而坏死部分增强较差，低于 31%。然而，不同造影剂的增强时程不同。 Gd-DTPA 往往在给药后很快提供最大的增强，并且在两个小时内没有显着变化。白蛋白-(Gd-DTPA) 的增强最初很弱，与肿瘤血管缺乏相对应，但在两个小时内，存活肿瘤区域的信号强度逐渐增加。大分子药物在肿瘤内逐渐积累被认为反映了与新生血管相关的毛细血管通透性异常。因此，肿瘤组织内的强度随着时间的推移而增加，反映了大分子的毛细血管通透性异常，可以作为有用的（尽管是间接的）肿瘤标志物。
The study aim was to define potential differences and advantages in magnetic resonance (MR) patterns of tumoral contrast enhancement using either a small molecular, extracellular fluid contrast enhancer [Gd-DTPA] or a macromolecular agent [albumin-(Gd-DTPA) 20], designed for primary intravascular biodistribution. MR images of 25 mice with implanted fibrosarcomas were obtained before and repeatedly for up to 120 minutes after injection of either Gd-DTPA [0.2 mmol/kg, n= 11] or albumin-(Gd-DTPA)[O. 0029 mmol/kg, n= 14]. Histologically, this hypovascular tumor contained zones of viable tissue and non-viable, necrotic tissue. Using either type of contrast media, the viable portions enhanced strongly, up to 152% and the necrotic portions enhanced poorly, less than 31%. However, the time-course of enhancement differed between contrast agents. Gd-DTPA tended to provide maximal enhancement soon after administration with no significant changes over two hours. Enhancement from albumin-(Gd-DTPA) was weak initially, corresponding to tumor hypovascularity, but over two hours the signal of the viable tumor zones progressively increased in intensity. This gradual tumoral accumulation of the macromolecular agent within the tumor was considered to reflect abnormal capillary permeability, associated with neovascularity. Thus, the increasing intensity within the neoplastic tissues over time, reflecting abnormal capillary permeability for macromolecules, may serve as a useful, albeit indirect, marker of neoplasia.