A Central Auditory Test reveals differences between drug treatment regimens in adults living with HIV.
A Central Auditory Test reveals differences between drug treatment regimens in adults living with HIV.
复制标题
中央听觉测试揭示了成人艾滋病毒感染者药物治疗方案之间的差异。
DOI：
10.1080/14992027.2023.2168217
复制
发表时间：
2024
影响因子：
2.7
通讯作者：
Shi,Yuxin
中科院分区：
文献类型：
--
作者：
Niemczak,ChristopherE;Zhan,Yi;Ren,Junkun;Song,Fengxiang;Lu,Hongzhou;Chen,Guochao;Fellows,AbigailM;Gui,Jiang;Soli,SigfridD;Buckey,JayC;Shi,Yuxin
目的：本探索性研究探讨两种主要抗逆转录病毒药物治疗（ART）方案治疗的HIV感染者（PLWH）的中枢听觉测试是否存在差异。研究样本253名来自中国上海公共卫生临床中心的PLWH（平均年龄39.8岁）。方法采用噪音听力测试语音接收阈值（SRT）评估中枢听觉功能，蒙特利尔认知评估（MoCA）评估认知功能。ART方案与SRT之间的关系通过多变量线性回归评估，包括年龄、HIV持续时间和外周听力能力。采用多变量logistic回归确定SRT和ART方案是否预测MoCA损伤。结果两种主要抗逆转录病毒治疗方案的差异在于一种药物（齐多夫定或替诺福韦）。服用含齐多夫定方案的参与者SRT表现较差（p= 0.012），与年龄和听力阈值无关。MoCA评分在不同药物方案之间没有差异，但SRT与MoCA损伤呈负相关（p= 0.048）。结论抗逆转录病毒治疗方案与中枢听觉测试成绩的相关性不同，可能反映了服用含齐多夫定方案的PLWH的神经认知变化。中枢听觉测试的表现也能轻微预测认知障碍，支持进一步评估中枢听觉测试来检测PLWH的神经认知缺陷。
ObjectiveThis exploratory study examined whether central auditory tests show differences between people living with HIV (PLWH) treated with two predominant antiretroviral drug therapy (ART) regimens.DesignCross-sectional.Study Sample253 PLWH (mean age 39.8 years) from the Shanghai Public Health Clinical Centre, China.MethodsThe Hearing in Noise Test speech reception threshold (SRT) assessed central auditory function and the Montreal Cognitive Assessment (MoCA) assessed cognition. The relationship between ART regimen and SRT was evaluated with multivariable linear regression incorporating age, HIV duration, and peripheral hearing ability. Multivariable logistic regression was used to ascertain if SRT and ART regimen predicted MoCA impairment.ResultsThe two predominant ART regimens differed by one drug (zidovudine or tenofovir). Participants taking the zidovudine-containing regimen had poorer SRT performance (p=.012) independent of age and hearing thresholds. MoCA scores did not differ between drug regimens, but a negative relationship was found between SRT and MoCA impairment (p=.048).ConclusionsART regimens differed in their association with central auditory test performance likely reflecting neurocognitive changes in PLWH taking the zidovudine-containing regimen. Central auditory test performance also marginally predicted cognitive impairment, supporting further assessment of central auditory tests to detect neurocognitive deficits in PLWH.