The apolipoprotein E polymorphism in Greenland Inuit in its global perspective
The apolipoprotein E polymorphism in Greenland Inuit in its global perspective
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DOI：
10.1007/s004390050257
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发表时间：
1996-11-01
期刊：
影响因子：
5.3
通讯作者：
Dyerberg, J
中科院分区：
文献类型：
--
作者：
Gerdes, LU;Gerdes, C;Dyerberg, J
载脂蛋白 E (apoE) 基因型是在格陵兰岛西南海岸努克 (n = 100) 和东南海岸阿马萨利克地区 (n = 78) 的因纽特人样本中测定的。后者样本中不存在epsilon 2等位基因，epsilon 4等位基因频率相对较高，约为23%。与大多数其他人群一样，除高密度脂蛋白 (HDL) 胆固醇外，携带 epsilon 4 的因纽特男性和女性的平均血浆脂蛋白相关变量均高于 epsilon 3 epsilon 3 基因型（男性甘油三酯 P < 0.05，女性非 HDL 胆固醇和载脂蛋白 B）。将估计的 apoE 等位基因频率与其他原住民研究的数据相结合，勾勒出 apoE 等位基因频率的世界地图。最近对非人类灵长类动物的一项研究表明，epsilon 4 而不是 epsilon 3 是人类的祖先等位基因，我们使用该图谱生成了有关人类 apoE 多态性历史的其他假设。
Apolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The epsilon 2 allele was absent in the latter sample, and the epsilon 4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with epsilon 4 than in epsilon 3 epsilon 3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that epsilon 4, and not epsilon 3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.