Potassium Alkoxide/Disilane-Mediated Dehalogenative Deuteration
Potassium Alkoxide/Disilane-Mediated Dehalogenative Deuteration
复制标题
醇钾/乙硅烷介导的脱卤氘化
作者：
Wang Xin;Zhu Ming Hui;Liu Wen Bo
摘要 氘代化合物在化学和制药领域具有重要意义。还原脱卤是将氘掺入分子中的最有用的方法之一。本文简要讨论了脱卤氘化反应的历史发展，包括过渡金属催化、自由基卤素抽象、碱金属还原氘化以及最近开发的甲醇钾/六甲基乙硅烷介导的芳基卤化物脱卤反应。
Abstract Deuterated compounds are of great importance in chemistry and pharmaceuticals. Reductive dehalogenation is one of the most useful methods to incorporate deuterium into molecules. This article briefly discusses the historical development of dehalogenative deuteration reactions that involve transition-metal catalysis, radical halogen abstraction, alkali-metal reductive deuteration, and the recently developed potassium methoxide/hexamethyldisilane-mediated dehalogenation of aryl halides.