Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults.
Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults.
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DOI：
10.1371/journal.pone.0150825
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Avol E
中科院分区：
文献类型：
--
作者：
Breton CV;Mack WJ;Yao J;Berhane K;Amadeus M;Lurmann F;Gilliland F;McConnell R;Hodis HN;Künzli N;Avol E
暴露于环境空气污染物会增加成年人心血管健康不良后果的风险。我们的目的是评估产前空气污染物暴露对心血管健康的贡献，这还没有得到彻底的评估。青年测试反应（TROY）研究由2007-2009年从南加州大学招募的768名大学生组成。参与者参加了一次研究访问，在此期间评估了血压，心率和颈动脉动脉硬度（CAS）和颈动脉内膜中层厚度（CIMT）。产前居住地址进行地理编码，并用于分配产前和产后空气污染物暴露估计使用美国环境保护署的空气质量系统（AQS）数据库。采用线性回归分析方法对CAS、CIMT与大气污染物之间的关系进行了评估。出生前PM10和PM2.5暴露与CAS增加有关。例如，产前PM2.5增加2 SD与CAS指数相关，包括增加5%（β = 1.05，95% CI 1.00-1.10）颈动脉僵硬指数β增加5%杨氏弹性模量（β = 1.05，95% CI 1.01-1.10）和扩张性降低5%（β = 0.95，95% CI 0.91-0.99）。出生前和出生后PM2.5的相互校正模型进一步表明，产前暴露是CAS最相关的暴露期。未观察到与CIMT相关。总之，产前暴露于升高的空气污染物可能会增加颈动脉僵硬的年轻成年人口的大学生。旨在限制产前暴露的努力是重要的公共卫生目标。
Exposure to ambient air pollutants increases risk for adverse cardiovascular health outcomes in adults. We aimed to evaluate the contribution of prenatal air pollutant exposure to cardiovascular health, which has not been thoroughly evaluated. The Testing Responses on Youth (TROY) study consists of 768 college students recruited from the University of Southern California in 2007–2009. Participants attended one study visit during which blood pressure, heart rate and carotid artery arterial stiffness (CAS) and carotid artery intima-media thickness (CIMT) were assessed. Prenatal residential addresses were geocoded and used to assign prenatal and postnatal air pollutant exposure estimates using the U.S. Environmental Protection Agency’s Air Quality System (AQS) database. The associations between CAS, CIMT and air pollutants were assessed using linear regression analysis. Prenatal PM10 and PM2.5 exposures were associated with increased CAS. For example, a 2 SD increase in prenatal PM2.5 was associated with CAS indices, including a 5% increase (β = 1.05, 95% CI 1.00–1.10) in carotid stiffness index beta, a 5% increase (β = 1.05, 95% CI 1.01–1.10) in Young’s elastic modulus and a 5% decrease (β = 0.95, 95% CI 0.91–0.99) in distensibility. Mutually adjusted models of pre- and postnatal PM2.5 further suggested the prenatal exposure was most relevant exposure period for CAS. No associations were observed for CIMT. In conclusion, prenatal exposure to elevated air pollutants may increase carotid arterial stiffness in a young adult population of college students. Efforts aimed at limiting prenatal exposures are important public health goals.