Circulating Inflammation Proteins Associated With Lung Cancer in African Americans
Circulating Inflammation Proteins Associated With Lung Cancer in African Americans
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DOI：
10.1016/j.jtho.2019.03.014
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发表时间：
2019-07-01
影响因子：
20.4
通讯作者：
Ryan, Brid M.
中科院分区：
文献类型：
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作者：
Meaney, Claire L.;Mitchell, Khadijah A.;Ryan, Brid M.
在美国，非裔美国人（AAs）的肺癌发病率高于欧洲裔美国人（EAs）。我们和其他人以前已经显示了免疫和炎症蛋白与EA中肺癌之间的关系。我们的目的是探讨炎症和肺癌之间的病因学关系在AA。方法：我们采用了两阶段，独立的研究设计（发现病例，n = 316;对照病例，n = 509）（验证病例，n = 399;对照病例，n = 400对照），并使用Meso Scale Discovery V-PLEX多重测定法测量血液中的30种炎症蛋白。我们在AAS中鉴定并验证了10种与肺癌相关的蛋白质，其中一些蛋白质在EA和AA之间是常见的（C-反应蛋白[OR：2.90; 95%置信区间（CI）：1.99-4.22]、干扰素γ [OR：1.55; 95% CI：1.10-2.19]、白细胞介素6 [OR：6.28; 95% CI：4.10-9.63]，白细胞介素8 [OR：2.76; 95% CI：1.92-3.98]），有些仅在AA中观察到（白细胞介素10 [OR：1.69; 95%CI：1.20-2.38]、白细胞介素15 [OR：2.83; 95%CI：1.96-4.07]、干扰素γ诱导蛋白10 [OR：1.54; 95%CI：1.09-2.18]、单核细胞趋化蛋白-4 [OR：0.54; 95%CI：0.38-0.76]、巨噬细胞炎性蛋白-1 α [OR：1.57; 95%CI：1.12-2.21]和肿瘤坏死因子β [OR：0.52; 95%CI：0.37-0.74]）。我们没有发现证据表明，无论是薄荷醇香烟吸烟或全球遗传血统驱动这些人口differentiation.Conclusions：我们的研究结果突出了一个独特的炎症特征与肺癌相关的AAs相比，EA。这些数据提供了新的见解肺癌的病因学在AA。需要进一步的工作来了解是什么驱动了这种与肺癌的关系，以及这些蛋白质是否在早期诊断中具有实用性。爱思唯尔公司出版国际肺癌研究协会的代表。
Introduction: Lung cancer incidence is higher among African Americans (AAs) compared with European Americans (EAs) in the United States. We and others have previously shown a relationship between immune and inflammation proteins with lung cancer in EAs. Our aim was to investigate the etiologic relationship between inflammation and lung cancer in AAs.Methods: We adopted a two-stage, independent study design (discovery cases, n = 316; control cases, n = 509) (validation cases, n = 399; control cases, n = 400 controls) and measured 30 inflammation proteins in blood using Meso Scale Discovery V-PLEX multiplex assays.Results: We identified and validated 10 proteins associated with lung cancer in AAS, some that were common between EAs and AAs (C-reactive proteins [OR: 2.90; 95% confidence interval (CI): 1.99-4.22], interferon gamma [OR: 1.55; 95% CI: 1.10-2.19], interleukin 6 [OR: 6.28; 95% CI: 4.10-9.63], interleukin 8 [OR: 2.76; 95% CI: 1.92-3.98]) and some that are only observed among AAs (interleukin 10 [OR: 1.69; 95% CI: 1.20-2.38], interleukin 15 [OR: 2.83; 95% CI: 1.96-4.07], interferon gamma-induced protein 10 [OR: 1.54; 95% CI: 1.09-2.18], monocyte chemotactic protein-4 [OR: 0.54; 95% CI: 0.38-0.76], macrophage inflammatory protein-1 alpha [OR: 1.57; 95% CI: 1.12-2.21], and tumor necrosis factor beta [OR: 0.52; 95% CI: 0.37-0.74]). We did not find evidence that either menthol cigarette smoking or global genetic ancestry drove these population differences.Conclusions: Our results highlight a distinct inflammation profile associated with lung cancer in AAs compared with EAs. These data provide new insight into the etiology of lung cancer in AAs. Further work is needed to understand what drives this relationship with lung cancer and whether these proteins have utility in the setting of early diagnosis. Published by Elsevier Inc. on behalf of International Association for the Study of Lung Cancer.