Method to determine in vivo the relaxation time T1 of hyperpolarized xenon in rat brain
Method to determine in vivo the relaxation time T1 of hyperpolarized xenon in rat brain
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DOI：
10.1002/mrm.10471
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发表时间：
2003-06-01
影响因子：
3.3
通讯作者：
Ziegler, A
中科院分区：
文献类型：
--
作者：
Choquet, P;Hyacinthe, JN;Ziegler, A
通过光学技术可以显著增强稳定同位素129的磁极化，并且原则上，超极化129 MRI应该允许以比磁共振成像技术更好的空间分辨率定量绘制脑血流。这种定量所需的参数，以前不知道的，是纵向弛豫时间，（T-1（组织））在体内脑组织中的α-129：用于确定这一点的方法报告。使用扩展的二室模型分析了动脉注射超极化的脂肪乳剂中的P129期间脑中MR信号的时程。该模型使用脂肪乳剂中RF翻转角和T-I的实验测定值。在2.35 T下对大鼠进行体内测量，得出T-1（组织）= 3.6 +/- 2.1 sec（+/-SD，n = 6）。该方法能够定量绘制脑血流量。(C)2003 Wiley-Liss，Inc.
The magnetic polarization of the stable Xe-129 isotope may be enhanced dramatically by means of optical techniques and, in principle, hyperpolarized Xe-129 MRI should allow quantitative mapping of cerebral blood flow with better spatial resolution than scintigraphic techniques. A parameter necessary for this quantitation, and not previously known, is the longitudinal relaxation time, (T-1(tissue)) of Xe-129 in brain tissue in vivo: a method for determining this is reported. The time course of the MR signal in the brain during arterial injection of hyperpolarized Xe-129 in a lipid emulsion was analyzed using an extended two-compartment model. The model uses experimentally determined values of the RF flip angle and the T-1 of Xe-129 in the lipid emulsion. Measurements on rats, in vivo, at 2.35 T gave T-1(tissue) = 3.6 +/- 2.1 sec (+/-SD, n = 6). This method enables quantitative mapping of cerebral blood flow. (C) 2003 Wiley-Liss, Inc.