Graphene-Based SELDI Probe with Ultrahigh Extraction and Sensitivity for DNA Oligomer
Graphene-Based SELDI Probe with Ultrahigh Extraction and Sensitivity for DNA Oligomer
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DOI：
10.1021/ja104017y
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发表时间：
2010-08-18
影响因子：
15
通讯作者：
Loh, Kian Ping
中科院分区：
文献类型：
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作者：
Tang, Lena Ai Ling;Wang, Junzhong;Loh, Kian Ping
我们证明了石墨烯可以作为单链DNA的超高效预富集和检测平台。DNA吸附的石墨烯可直接用于表面增强激光解吸电离飞行时间质谱仪(SELDI-TOF-MS)。生物分子的快速富集和直接的、无标记的检测在蛋白质组学和基因组学的分析中具有潜在的实用价值。
We demonstrate that graphene can be used as an ultrahigh efficiency preconcentration and detection platform for ssDNA. DNA-adsorbed graphene can be used directly for Surface Enhanced Laser Desorption Ionization-Time of Flight-Mass Spectrometry (SELDI-TOF-MS). The rapid enrichment of biomolecules and direct, label-free detection are potentially useful for analysis in proteomics and genomics.