Incidence and prevalence of CIDP and the association of diabetes mellitus
Incidence and prevalence of CIDP and the association of diabetes mellitus
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DOI：
10.1212/wnl.0b013e3181aaea47
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发表时间：
2009-07-07
期刊：
影响因子：
9.9
通讯作者：
Dyck, P. J. B.
中科院分区：
文献类型：
--
作者：
Laughlin, R. S.;Dyck, P. J.;Dyck, P. J. B.
背景：据报道，慢性炎症性脱髓鞘性多发性神经根神经病 (CIDP) 的患病率差异很大，从每 10 万人 1.9 人到 7.7 人不等。据报道，CIDP 在糖尿病 (DM) 患者中更常见，但尚未经过严格测试。目的：确定明尼苏达州奥姆斯特德县 CIDP 的发病率（1982-2001 年）和患病率（2000 年 1 月 1 日），以及 CIDP 中 DM 是否更常见。方法：根据临床标准诊断 CIDP，然后进行电生理学检查。案例被编码为确定的、可能的或可能的。 DM 通过临床诊断或现行美国糖尿病协会血糖标准来确定。结果：审查了 1581 份医疗记录，23 名患者（10 名女性和 13 名男性）被确定患有 CIDP（19 名确诊患者和 4 名可能患者）。中位年龄为 58 岁（范围 4-83 岁），诊断时的中位病程为 10 个月（范围 2-64 个月）。 CIDP的发病率为1.6/10万人/年。 2000年1月1日患病率为8.9/10万人。23名CIDP患者中只有1人(4%)患有DM，而115名年龄和性别匹配的对照者中有14人(12%)患有DM。结论：1)慢性炎症的发病率(1.6/10万/年)和患病率(8.9/10万)脱髓鞘性多发性神经根神经病（CIDP）与之前的估计相似或更高。 2）同一人群中CIDP的发病率与急性炎症性脱髓鞘性多发性神经根神经病相似。 3) 糖尿病 (DM) 不太可能是 CIDP 的主要风险协变量，但我们不能排除小的影响。 4) DM 与 CIDP 的关联可能是由于对其他形式的糖尿病神经病变的错误分类以及过度强调电生理标准所致。神经病学（R）2009； 73：39-45
Background: The reported prevalence of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) varies greatly, from 1.9 to 7.7 per 100,000. CIDP is reported to occur more commonly in patients with diabetes mellitus (DM) but has not been rigorously tested. Objectives: To determine the incidence (1982-2001) and prevalence (on January 1, 2000) of CIDP in Olmsted County, Minnesota, and whether DM is more frequent in CIDP.Methods: CIDP was diagnosed by clinical criteria followed by review of electrophysiology. Cases were coded as definite, probable, or possible. DM was ascertained by clinical diagnosis or current American Diabetes Association glycemia criteria.Results: One thousand five hundred eighty-one medical records were reviewed, and 23 patients (10 women and 13 men) were identified as having CIDP (19 definite and 4 probable). The median age was 58 years (range 4-83 years), with a median disease duration at diagnosis of 10 months (range 2-64 months). The incidence of CIDP was 1.6/100,000/year. The prevalence was 8.9/100,000 persons on January 1, 2000. Only 1 of the 23 CIDP patients (4%) also had DM, whereas 14 of 115 age-and sex-matched controls (12%) had DM.Conclusions: 1) The incidence (1.6/100,000/year) and prevalence (8.9/100,000) of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are similar to or higher than previous estimates. 2) The incidence of CIDP is similar to that of acute inflammatory demyelinating polyradiculoneuropathy within the same population. 3) Diabetes mellitus (DM) is unlikely to be a major risk covariate for CIDP, but we cannot exclude a small effect. 4) The perceived association of DM with CIDP may be due to misclassification of other forms of diabetic neuropathies and excessive emphasis on electrophysiologic criteria. Neurology (R) 2009; 73: 39-45