RESERVOIR OF 4 ORGANISMS ASSOCIATED WITH BACTERIAL VAGINOSIS SUGGESTS LACK OF SEXUAL TRANSMISSION
RESERVOIR OF 4 ORGANISMS ASSOCIATED WITH BACTERIAL VAGINOSIS SUGGESTS LACK OF SEXUAL TRANSMISSION
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DOI：
10.1128/jcm.28.9.2035-2039.1990
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发表时间：
1990-09-01
影响因子：
9.4
通讯作者：
HOLST, E
中科院分区：
文献类型：
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作者：
HOLST, E
这项研究包括寻找四种与细菌性阴道病相关的微生物Mobiluncus mulieris、Mobiluncus curtisii、人支原体和阴道加德纳菌的可能宿主和传播方式。研究人员对患有和不患有细菌性阴道病的女性、她们的男性伴侣、四名同性恋男性和儿童（总共 374 人）的直肠、口腔和咽部标本中的情况进行了研究。还从所有成年人身上获取了生殖器样本。所有四种微生物均从 45% 至 62% 患有细菌性阴道病的女性和 10% 至 14% 的无细菌性阴道病女性的直肠中分离出来。它们也发生在男性和儿童的直肠中。从 12 名成人的口咽部中发现了人型支原体，这些成人的性配偶具有该生物体的生殖器。 Mobiluncus spp。仅发生在患有细菌性阴道病的女性的阴道中（97%）。这些生物体很少从 135 名男性的生殖器样本中回收到。 在 44 名患有细菌性阴道病的女性男性伴侣中，从 10 名的尿道和/或冠状沟中回收了微生物。然而，在性交过程中使用安全套两周后，一名男子的尿道中只剩下人型支原体。这些发现表明，与细菌性阴道病相关的微生物不是通过性传播，而是从内源性肠道部位定植于阴道。导致所有女性亚群细菌性阴道病的病理生理机制仍不清楚。
This study consisted of a search for the possible reservior and mode of spread of the four bacterial vaginosis-associated organisms Mobiluncus mulieris, Mobiluncus curtisii, Mycoplasma hominis, and Gardnerella vaginalis. Their occurrence in rectal, oral, and pharygneal specimens from women with and without bacterial vaginosis, their male sexual consorts, four homosexual men, and children (altogether, 374 people) was studied. Genital samples were also obtained from all adults. All four organisms were isolated from the rectums of 45 to 62% of women with bacterial vaginosis and 10 to 14% of women without bacterial vaginosis. They also occurred in the rectums of males and children. M. hominis was recovered from the oropharynxes of 12 adults whose sexual consorts had genital occurrences of the organism. Mobiluncus spp. occurred only in the vaginas of women with bacterial vaginosis (97%). The organisms were only infrequently recovered from genital samples from 135 males. Organisms were recovered from the urethras and/or coronal sulci of 10 of 44 male consorts of women with bacterial vaginosis. However, after 2 weeks of condom use during sexual intercourse, only M. hominis remained in the urethra of one man. These findings suggest that the organisms associated with bacterial vaginosis are not spread sexually but colonize the vagina from an endogenous intestinal tract site. The pathophysiological mechanisms leading to bacteria vaginosis in a subpopulation of all women are still unknown.