Association between bisphenol A exposure and body mass index in Chinese school children: a cross-sectional study.
Association between bisphenol A exposure and body mass index in Chinese school children: a cross-sectional study.
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DOI：
10.1186/1476-069x-11-79
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发表时间：
2012-10-19
期刊：
影响因子：
--
通讯作者：
Jiang QW
中科院分区：
文献类型：
--
作者：
Wang HX;Zhou Y;Tang CX;Wu JG;Chen Y;Jiang QW
越来越多的证据表明，双酚A（BPA）是全球产量最高的化学物质之一，它会干扰人体的自然体重控制机制，从而导致肥胖。然而，这方面的流行病学研究是有限的，特别是对儿童。本研究采用横断面研究的方法，调查了在校儿童BPA暴露与身体质量指数（BMI）之间的关系。从上海市长宁区的26所小学和30所中学中随机抽取了3所小学和3所中学。根据BMI为基础的超重或肥胖儿童的年龄和性别筛选标准，我们随机选择了20名肥胖，10名超重，30名正常体重的儿童，年龄在8-15岁，从每个选定的学校。收集第一次晨尿，用超高效液相色谱串联质谱法测定总尿BPA浓度。多元线性回归分析，以检查尿BPA浓度和每日摄入量估计与BMI的关联。在84.9%的尿样中检测到BPA，几何平均值为0.45 ng/mL。每日摄入量估计值范围为0.03 μg/天至1.96 μg/天，几何平均值为0.37 μg/天。男孩和女孩的平均尿BPA浓度和每日摄入量估计值相似，但年龄较大的儿童明显高于年龄较小的儿童，并显示出随着BMI增加的趋势。多元线性回归分析显示，在调整年龄和性别后，所有受试者的尿BPA浓度与BMI值的增加显著相关，并且经尿比重校正前后的结果相似。当按年龄或性别分层时，在用比重校正之前，女性和8-11岁的儿童中的相关性仍然显著。BMI和每日摄入量估计值之间的关联也显示了类似的结果。BPA暴露可能会增加学龄儿童的BMI。鉴于本研究的横截面性质，纵向研究有必要确认BPA暴露是儿童BMI增加的一个因素。
There is increasing evidence suggesting that Bisphenol A (BPA), one of the highest volume chemicals produced worldwide, can interfere with the body’s natural weight control mechanisms to promote obesity. However, epidemiological studies for this are limited, especially for children. A cross-sectional study was conducted to investigate the association between BPA exposure and body mass index (BMI) in school children. Three primary and three middle schools were randomly selected from 26 primary and 30 middle candidate schools in Changning District of Shanghai City in China. According to the BMI-based criteria by age and sex for screening of overweight or obese children, we randomly chose 20 obese, 10 overweight, and 30 normal weight children aged 8-15 years of age from each selected school. First morning urine was collected and total urine BPA concentrations were determined by ultra-performance liquid chromatography tandem mass spectrometry. Multiple linear regression analysis was conducted to examine the association of urine BPA concentrations and daily intake estimates with BMI. BPA was detected in 84.9% of urine samples with a geometric mean of 0.45 ng/mL. The daily intake estimates ranged from 0.03 μg/day to 1.96 μg/day with a geometric mean of 0.37 μg/day. The average urine BPA concentrations and daily intake estimates were similar for boys and girls, but significantly higher in older children than younger ones, and showed an increasing trend with BMI. Multiple linear regression analyses showed that urine BPA concentrations were significantly associated with increasing BMI values in all subjects after adjustment for age and sex and the results were similar before and after corrected by urine specific gravity. When stratified by age or sex, the associations remained significant in females and in those 8-11 years of age before corrected by specific gravity. Similar results were shown for the association between BMI and daily intake estimates. There is a possibility that BPA exposure increases BMI in school children. Given the cross-sectional nature of this study, longitudinal studies are warranted to confirm BPA exposure as a contributor to increased BMI in children.