Attenuated frontal activation during a verbal fluency task in patients with schizophrenia
Attenuated frontal activation during a verbal fluency task in patients with schizophrenia
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DOI：
10.1176/ajp.155.8.1056
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发表时间：
1998-08-01
影响因子：
17.7
通讯作者：
McGuire, PK
中科院分区：
文献类型：
--
作者：
Curtis, VA;Bullmore, ET;McGuire, PK
目的：应用功能磁共振成像技术研究精神分裂症患者在言语流利性任务中脑血氧含量的变化。方法：5名右撇子男性精神分裂症患者和5名志愿者参加研究，他们在人口统计学变量和言语流利性表现上匹配。受试者执行两项任务时，在1.5T下进行超过5分钟的回声平面图像采集。第一个实验涉及以听觉提示字母开始的有节奏的无声生成单词。这项任务伴随着有节奏的默默重复听觉呈现的单词“休息”。通过正弦回归和非参数假设检验，从个体图像构建通用脑激活图。实验反应平均功率的组间差异是在体素基础上通过协方差分析来确定的，该协方差分析控制了刺激相关运动的组间差异。结果：对照组在左侧前额叶皮质、双侧脑岛、中线辅助运动区和内侧顶叶皮质均有显著反应。与这些受试者相比，精神分裂症受试者在左侧背侧前额叶皮质、额下回和脑岛的反应能力显著降低，而在内侧顶叶皮质的反应能力显著增加。在两组患者中，额叶和顶叶反应呈负相关。结论：精神分裂症患者在词汇生成过程中多个额叶区域的反应能力减弱，但在词汇重复过程中内侧顶叶皮质的反应能力更强。
Objective: Functional magnetic resonance imaging was used to study changes in cerebral blood oxygenation in schizophrenic patients during a verbal fluency task. Method: Five right-handed male schizophrenic patients and five volunteers matched on demographic variables and verbal fluency performance participated in the study. Echoplanar images were acquired over 5 minutes at 1.5 T while the subjects performed two tasks. The first involved paced silent generation of words beginning with an aurally presented cue letter. This task alternated with paced silent repetition of the aurally presented word "rest." Generic brain activation maps were constructed from individual images by sinusoidal regression and nonparametric hypothesis testing. Between-group differences in the mean power of experimental response were identified on a voxelwise basis by an analysis of covariance that controlled for between-group differences in stimulus-correlated motion. Results: The comparison group showed significant responses in the left prefrontal cortex, the insula bilaterally, the midline supplementary motor area, and the medial parietal cortex. Compared to those subjects, the schizophrenic subjects showed significantly reduced power of response in the left dorsal prefrontal cortex, the inferior frontal gyrus, and the insula but significantly increased power of response in the medial parietal cortex. In both groups frontal and parietal responses were negatively correlated. Conclusions: Schizophrenic patients displayed attenuated power of response in several frontal regions during word generation but greater power of response in the medial parietal cortex during word repetition.