Fluorescein and indocyanine-green angiography in ocular syphilis: an exploratory study
Fluorescein and indocyanine-green angiography in ocular syphilis: an exploratory study
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眼梅毒荧光素和吲哚菁绿血管造影：一项探索性研究
DOI：
10.1007/s00417-011-1893-4
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Y. Guex
中科院分区：
文献类型：
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作者：
K. Balaskas;T. Sergentanis;S. Giulieri;Y. Guex
背景荧光素（FA）和吲哚青绿血管造影（ICGA）可为眼梅毒的病情严重程度和预后提供有价值的信息。本研究的目的是描述眼梅毒的血管造影模式，并探讨特定血管造影表现与疾病严重程度之间的关系，我们进行了一项回顾性研究，纳入了23例在Jules-Gonin眼科医院葡萄膜炎门诊就诊的眼梅毒患者，年期间。FA和ICGA按照后葡萄膜炎的标准方案进行。荧光模式，并指出，每个血管造影模式和任何人口统计学，临床，或实验室参数之间的统计学关联在基线和治疗后searched.ResultsThe ICGA中的任何暗点的存在显着相关的前葡萄膜炎（p= 0.031）。ICGA中热点的存在与首次访视前症状持续时间较长（p= 0.032）和男性（p= 0.012）显著相关。发现FA中的血管染色与前葡萄膜炎（p= 0.066）、玻璃体炎（p= 0.069）和较年轻（p= 0.061）相关，FA中的视盘高荧光与HIV血清阳性（p= 0.089）相关，FA中的黄斑水肿与病程较长（p= 0.061）相关。ICGA中的任何暗点的存在表现出与前葡萄膜炎和/或玻璃体炎（p= 0.079）的关联的微弱趋势。ConclusionsOut的几个协会确定牵连特定的血管造影功能，我们强调可能的作用，在ICGA中的暗点的存在，以确定活动性炎症，和ICGA中的热点作为长期疾病的标志物的作用。FA中的血管染色似乎在伴有前葡萄膜炎和/或玻璃体炎的严重眼部炎症患者中更常见。
BackgroundFluorescein (FA) and indocyanine-green angiography (ICGA) may offer valuable information concerning disease severity and prognosis in ocular syphilis. The aim of the present study is to describe angiographic patterns encountered in the context of ocular syphilis, and to explore the associations between specific angiographic manifestations and severity of disease presentation, as well as disease evolution after treatment.MethodsWe performed a retrospective institutional study with the inclusion of 23 patients with ocular syphilis presenting to the uveitis clinic of the Jules-Gonin Eye Hospital in a 10-year period. FA and ICGA were performed following a standard protocol for posterior uveitis. Patterns of fluorescence were noted, and statistical associations between each angiographic pattern and any demographic, clinical, or laboratory parameter at baseline and after treatment were sought.ResultsThe presence of any dark dots in ICGA was significantly associated with anterior uveitis (p= 0.031). The presence of hot spots in ICGA was significantly associated with longer duration of symptoms prior to initial visit (p= 0.032) and with male gender (p= 0.012). Weak non-significant trends were found associating vascular staining in FA with anterior uveitis (p= 0.066), vitritis (p= 0.069), and younger age (p= 0.061), as well as disc hyperfluorescence in FA with seropositivity for HIV (p= 0.089) and macular edema in FA with longer disease duration (p= 0.061). The presence of any dark dots in ICGA exhibited a weak trend of association with anterior uveitis and/or vitritis (p= 0.079).ConclusionsOut of the several associations identified implicating specific angiographic features, we underline the possible role of the presence of dark dots in ICGA for identifying active inflammation, and the role of hot spots in ICGA as markers of long-standing disease. Vascular staining in FA appears to be more common in patients with severe ocular inflammation with presence of anterior uveitis and/or vitritis.