ERRATIC G-]A HYPERMUTATION WITHIN A COMPLETE CAPRINE ARTHRITIS-ENCEPHALITIS VIRUS (CAEV) PROVIRUS
ERRATIC G-]A HYPERMUTATION WITHIN A COMPLETE CAPRINE ARTHRITIS-ENCEPHALITIS VIRUS (CAEV) PROVIRUS
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DOI：
10.1006/viro.1995.1261
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发表时间：
1995-06-01
期刊：
影响因子：
3.7
通讯作者：
HENRY, M
中科院分区：
文献类型：
--
作者：
WAINHOBSON, S;SONIGO, P;HENRY, M
山羊关节炎-脑炎病毒（CAEV）整合前病毒的全核苷酸序列已被测定。由于广泛的G -> A超突变，原病毒是有缺陷的。而不是一个平滑的现象分布在整个基因组中，它是高度不稳定的高度突变和正常的区域被并列，可能反映了在CAEV基因组的逆转录过程中的细胞内dCTP池的局部波动。表面糖蛋白内的序列变异模式与灵长类慢病毒的序列变异模式略有不同。(C)出版社：Academic Press
The complete nucleotide sequence of an integrated provirus of caprine arthritis-encephalitis virus (CAEV) has been determined. The provirus was defective due to extensive G --> A hypermutation. Rather than being a smooth phenomenon distributed throughout the genome it was highly erratic with hypermutated and normal regions being juxtaposed, probably reflecting local fluctuations in the intracellular dCTP pool during reverse transcription of the CAEV genome. The pattern of sequence Variation within the surface glycoproteins differs subtly from that of the primate lentiviruses. (C) 1995 Academic Press, Inc.